Roni T Fleischer1, Beverley J Vollenhoven, Gareth C Weston. 1. Department of Obstetrics & Gynaecology, Level 5 Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia. roni.fleischer@southernhealth.org.au
Abstract
UNLABELLED: With the improved survival rate of childhood and young adult cancer patients, the long-term sequelae of the treatments used are increasingly important. In this review, current knowledge of the gonadotoxicity of commonly employed chemotherapeutic agents and radiotherapy regimens is examined. Differences between the effect of "high-risk" and "low-risk" agents are discussed. Tailoring treatment to suit the individual and counseling patients regarding reduced fertility have resulted in the best practice. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completing this CME activity, physicians should be better able to evaluate and use appropriate methods to estimate ovarian reserve, assess the risk of infertility caused by commonly used cytotoxic chemotherapy regimens and radiation, and counsel patients regarding the gonadotoxic effects of cancer treatment.
UNLABELLED: With the improved survival rate of childhood and young adult cancerpatients, the long-term sequelae of the treatments used are increasingly important. In this review, current knowledge of the gonadotoxicity of commonly employed chemotherapeutic agents and radiotherapy regimens is examined. Differences between the effect of "high-risk" and "low-risk" agents are discussed. Tailoring treatment to suit the individual and counseling patients regarding reduced fertility have resulted in the best practice. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completing this CME activity, physicians should be better able to evaluate and use appropriate methods to estimate ovarian reserve, assess the risk of infertility caused by commonly used cytotoxic chemotherapy regimens and radiation, and counsel patients regarding the gonadotoxic effects of cancer treatment.
Authors: Magdalena Tarkowska; Iwona Głowacka-Mrotek; Bartosz Skonieczny; Tomasz Nowikiewicz; Michał Tarkowski; Michał Jankowski; Wojciech Zegarski; Piotr Jarzemski Journal: Curr Oncol Date: 2022-05-05 Impact factor: 3.109
Authors: Adriana Valentini; Amy Finch; Jan Lubinski; Tomasz Byrski; Parviz Ghadirian; Charmaine Kim-Sing; Henry T Lynch; Peter J Ainsworth; Susan L Neuhausen; Ellen Greenblatt; Christian Singer; Ping Sun; Steven A Narod Journal: J Clin Oncol Date: 2013-08-26 Impact factor: 44.544
Authors: Sigrid Marie Kraggerud; Christina E Hoei-Hansen; Sharmini Alagaratnam; Rolf I Skotheim; Vera M Abeler; Ewa Rajpert-De Meyts; Ragnhild A Lothe Journal: Endocr Rev Date: 2013-04-10 Impact factor: 19.871