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Literature DB >> 6508745

Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.

Abstract

Dichloroacetate (which activates pyruvate dehydrogenase) decreases the release of alanine, pyruvate and lactate in hemidiaphragm incubations with valine. Dichloroacetate interferes with alanine formation by diverting pyruvate into oxidative pathways, which not only limits pyruvate availability for direct transamination to form alanine but also indirectly affects branched-chain amino acid transamination by limiting 2-oxoglutarate regeneration from glutamate.

Entities: Chemical Species

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Year: 1984 PMID： 6508745 PMCID： PMC1144369 DOI： 10.1042/bj2230831

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

1. Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell.

Authors: G Hennig; G Löffler; O H Wieland
Journal: FEBS Lett Date: 1975-11-15 Impact factor: 4.124

2. The formation of alanine from amino acids in diaphragm muscle of the rat.

Authors: L Goldstein; E A Newsholme
Journal: Biochem J Date: 1976-02-15 Impact factor: 3.857

3. Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.

Authors: P J Blackshear; P A Holloway; K G Alberti
Journal: Biochem J Date: 1975-09 Impact factor: 3.857

4. Oxidation of amino acids by diaphragms from fed and fasted rats.

Authors: A L Goldberg; R Odessey
Journal: Am J Physiol Date: 1972-12

5. Effects of dichloroacetate on the lactate/pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells.

Authors: W M Pardridge; L Duducgian-Vartavarian; D Casanello-Ertl
Journal: Biochem Pharmacol Date: 1983-01-01 Impact factor: 5.858

6. Assay of leucine aminotransferase in rat tissues and tumors.

Authors: C C Cappuccino; H Kadowaki; W E Knox
Journal: Enzyme Date: 1978

7. Studies on the regulation of leucine catabolism. II. Mechanism responsible for dichloroacetate stimulation of leucine oxidation by the liver.

Authors: R A Harris; D W Crabb; R M Sans
Journal: Arch Biochem Biophys Date: 1978-09 Impact factor: 4.013

8. Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate.

Authors: M N Goodman; N B Ruderman; T T Aoki
Journal: Diabetes Date: 1978-11 Impact factor: 9.461

9. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

Authors: S Whitehouse; R H Cooper; P J Randle
Journal: Biochem J Date: 1974-09 Impact factor: 3.857

10. The release of alanine by rat diaphragm muscle in vitro.

Authors: K Snell; D A Duff
Journal: Biochem J Date: 1977-02-15 Impact factor: 3.857

7 in total

Review 1. Determination of the rate-limiting step(s) in the biosynthetic pathways leading to penicillin and cephalosporin.

Authors: J J Usher; D W Hughes; M A Lewis; S J Chiang
Journal: J Ind Microbiol Date: 1992-09

Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.

1. Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell.

2. The formation of alanine from amino acids in diaphragm muscle of the rat.

3. Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.

4. Oxidation of amino acids by diaphragms from fed and fasted rats.

5. Effects of dichloroacetate on the lactate/pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells.

6. Assay of leucine aminotransferase in rat tissues and tumors.

7. Studies on the regulation of leucine catabolism. II. Mechanism responsible for dichloroacetate stimulation of leucine oxidation by the liver.

8. Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate.

9. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

10. The release of alanine by rat diaphragm muscle in vitro.

Review 1. Determination of the rate-limiting step(s) in the biosynthetic pathways leading to penicillin and cephalosporin.

2. Amino acid catabolism by perfused rat hindquarter. The metabolic fates of valine.

3. Characteristics of acidic, basic and neutral amino acid transport in the perfused rat hindlimb.

4. Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation.

5. The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid.

6. Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle.

7. Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance.