Literature DB >> 16603349

Structure-activity studies of oxazolidinone analogs as RNA-binding agents.

John Means1, Steven Katz, Abhijit Nayek, Rajaneesh Anupam, Jennifer V Hines, Stephen C Bergmeier.   

Abstract

We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.

Entities:  

Mesh:

Substances:

Year:  2006        PMID: 16603349     DOI: 10.1016/j.bmcl.2006.03.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  22 in total

1.  Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles.

Authors:  S Zhou; G Acquaah-Harrison; S C Bergmeier; J V Hines
Journal:  Bioorg Med Chem Lett       Date:  2011-09-29       Impact factor: 2.823

2.  Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA.

Authors:  Crina M Orac; Shu Zhou; John A Means; David Boehm; Stephen C Bergmeier; Jennifer V Hines
Journal:  J Med Chem       Date:  2011-08-31       Impact factor: 7.446

3.  Structure-activity studies of RNA-binding oxazolidinone derivatives.

Authors:  Iwona Maciagiewicz; Shu Zhou; Stephen C Bergmeier; Jennifer V Hines
Journal:  Bioorg Med Chem Lett       Date:  2011-06-15       Impact factor: 2.823

Review 4.  Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.

Authors:  Katherine E Deigan; Adrian R Ferré-D'Amaré
Journal:  Acc Chem Res       Date:  2011-05-26       Impact factor: 22.384

5.  Small molecule-RNA targeting: starting with the fundamentals.

Authors:  Amanda E Hargrove
Journal:  Chem Commun (Camb)       Date:  2020-11-26       Impact factor: 6.222

6.  Ligand-induced changes in T box antiterminator RNA stability.

Authors:  Shu Zhou; George Acquaah-Harrison; Karen D Jack; Stephen C Bergmeier; Jennifer V Hines
Journal:  Chem Biol Drug Des       Date:  2011-12-22       Impact factor: 2.817

Review 7.  The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand.

Authors:  Tina M Henkin
Journal:  Biochim Biophys Acta       Date:  2014-05-09

8.  Discovering ligands for a microRNA precursor with peptoid microarrays.

Authors:  Sara Chirayil; Rachel Chirayil; Kevin J Luebke
Journal:  Nucleic Acids Res       Date:  2009-06-26       Impact factor: 16.971

Review 9.  The T box mechanism: tRNA as a regulatory molecule.

Authors:  Nicholas J Green; Frank J Grundy; Tina M Henkin
Journal:  FEBS Lett       Date:  2010-01-21       Impact factor: 4.124

10.  Factors that influence T box riboswitch efficacy and tRNA affinity.

Authors:  C Zeng; S Zhou; S C Bergmeier; J V Hines
Journal:  Bioorg Med Chem       Date:  2015-07-16       Impact factor: 3.641

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.