Literature DB >> 19839622

Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.

Yang Liu1, Eleanor Peacey, John Dickson, Christine P Donahue, Suxin Zheng, Gabriele Varani, Michael S Wolfe.   

Abstract

A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem-loop structure that serves as a splicing regulatory element in the pre-mRNA of tau, which is involved in Alzheimer's and other neurodegenerative diseases. Several compounds showed significantly improved binding activity relative to the original screening hit mitoxantrone. These findings establish essential structure-activity relationships to further optimize the activity of this promising class of compounds.

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Year:  2009        PMID： 19839622      PMCID： PMC3808193          DOI： 10.1021/jm9013407

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  15 in total

1.  Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.

Authors:  L Varani; M G Spillantini; M Goedert; G Varani
Journal:  Nucleic Acids Res       Date:  2000-02-01       Impact factor: 16.971

2.  Identification of tau stem loop RNA stabilizers.

Authors:  Christine P Donahue; Jake Ni; Eriks Rozners; Marcie A Glicksman; Michael S Wolfe
Journal:  J Biomol Screen       Date:  2007-05-24

3.  Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.

Authors:  X L Yang; H Robinson; Y G Gao; A H Wang
Journal:  Biochemistry       Date:  2000-09-12       Impact factor: 3.162

4.  A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition.

Authors:  F Hamy; V Brondani; A Flörsheimer; W Stark; M J Blommers; T Klimkait
Journal:  Biochemistry       Date:  1998-04-14       Impact factor: 3.162

5.  Structural modification study of mitoxantrone (DHAQ). Chloro-substituted mono- and bis[(aminoalkyl)amino]anthraquinones.

Authors:  R K Zee-Cheng; A E Mathew; P L Xu; R V Northcutt; C C Cheng
Journal:  J Med Chem       Date:  1987-09       Impact factor: 7.446

6.  Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.

Authors:  M Hutton; C L Lendon; P Rizzu; M Baker; S Froelich; H Houlden; S Pickering-Brown; S Chakraverty; A Isaacs; A Grover; J Hackett; J Adamson; S Lincoln; D Dickson; P Davies; R C Petersen; M Stevens; E de Graaff; E Wauters; J van Baren; M Hillebrand; M Joosse; J M Kwon; P Nowotny; L K Che; J Norton; J C Morris; L A Reed; J Trojanowski; H Basun; L Lannfelt; M Neystat; S Fahn; F Dark; T Tannenberg; P R Dodd; N Hayward; J B Kwok; P R Schofield; A Andreadis; J Snowden; D Craufurd; D Neary; F Owen; B A Oostra; J Hardy; A Goate; J van Swieten; D Mann; T Lynch; P Heutink
Journal:  Nature       Date:  1998-06-18       Impact factor: 49.962

Review 7.  Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.

Authors:  Carlo Ballatore; Virginia M-Y Lee; John Q Trojanowski
Journal:  Nat Rev Neurosci       Date:  2007-09       Impact factor: 34.870

8.  Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.

Authors:  M G Spillantini; J R Murrell; M Goedert; M R Farlow; A Klug; B Ghetti
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

9.  High field 1H-NMR analysis of the 1:1 intercalation complex of the antitumor agent mitoxantrone and the DNA duplex [d(CpGpCpG)].

Authors:  J W Lown; C C Hanstock
Journal:  J Biomol Struct Dyn       Date:  1985-06

Review 10.  A century of Alzheimer's disease.

Authors:  Michel Goedert; Maria Grazia Spillantini
Journal:  Science       Date:  2006-11-03       Impact factor: 47.728
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  19 in total

1.  G-quadruplex forming region within WT1 promoter is selectively targeted by daunorubicin and mitoxantrone: A possible mechanism for anti-leukemic effect of drugs.

Authors:  Saeedeh Ghazaey Zidanloo; Abasalt Hosseinzadeh Colagar; Hossein Ayatollahi; Zahra Bagheryan
Journal:  J Biosci       Date:  2019-03       Impact factor: 1.826

2.  Structure-activity studies of RNA-binding oxazolidinone derivatives.

Authors:  Iwona Maciagiewicz; Shu Zhou; Stephen C Bergmeier; Jennifer V Hines
Journal:  Bioorg Med Chem Lett       Date:  2011-06-15       Impact factor: 2.823

Review 3.  Design of small molecules targeting RNA structure from sequence.

Authors:  Andrei Ursu; Jessica L Childs-Disney; Ryan J Andrews; Collin A O'Leary; Samantha M Meyer; Alicia J Angelbello; Walter N Moss; Matthew D Disney
Journal:  Chem Soc Rev       Date:  2020-10-19       Impact factor: 54.564

4.  Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA.

Authors:  Yiling Luo; Matthew D Disney
Journal:  Chembiochem       Date:  2014-08-12       Impact factor: 3.164

Review 5.  RNA Structures as Mediators of Neurological Diseases and as Drug Targets.

Authors:  Viachaslau Bernat; Matthew D Disney
Journal:  Neuron       Date:  2015-07-01       Impact factor: 17.173

6.  Pituitary adenylate cyclase-activating polypeptide (PACAP) protects against mitoxantrone-induced cardiac injury in mice.

Authors:  Venkat Subramaniam; Gin Chuang; Huijing Xia; Brendan Burn; Jessica Bradley; Jerome L Maderdrut; David H Coy; Kurt J Varner
Journal:  Peptides       Date:  2017-07-15       Impact factor: 3.750

7.  Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Authors:  Simona Eleuteri; Saviana Di Giovanni; Edward Rockenstein; Mike Mante; Antony Adame; Margarita Trejo; Wolf Wrasidlo; Fang Wu; Patrick C Fraering; Eliezer Masliah; Hilal A Lashuel
Journal:  Neurobiol Dis       Date:  2014-08-28       Impact factor: 5.996

Review 8.  Small molecule recognition of disease-relevant RNA structures.

Authors:  Samantha M Meyer; Christopher C Williams; Yoshihiro Akahori; Toru Tanaka; Haruo Aikawa; Yuquan Tong; Jessica L Childs-Disney; Matthew D Disney
Journal:  Chem Soc Rev       Date:  2020-10-05       Impact factor: 54.564

9.  Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.

Authors:  Sai Pradeep Velagapudi; Matthew G Costales; Balayeshwanth R Vummidi; Yoshio Nakai; Alicia J Angelbello; Tuan Tran; Hafeez S Haniff; Yasumasa Matsumoto; Zi Fu Wang; Arnab K Chatterjee; Jessica L Childs-Disney; Matthew D Disney
Journal:  Cell Chem Biol       Date:  2018-06-28       Impact factor: 8.116

10.  Template-directed synthesis of a small molecule-antisense conjugate targeting an mRNA structure.

Authors:  Yang Liu; Lilia Rodriguez; Michael S Wolfe
Journal:  Bioorg Chem       Date:  2014-03-13       Impact factor: 5.275
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