Literature DB >> 2172289

Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture.

J A Levy1, A Landay, E T Lennette.   

Abstract

The SF strain of human herpesvirus 6 (HHV-6SF) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.

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Year:  1990        PMID： 2172289      PMCID： PMC268180          DOI： 10.1128/jcm.28.10.2362-2364.1990

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  12 in total

1.  Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.

Authors:  J A Hoxie; J D Alpers; J L Rackowski; K Huebner; B S Haggarty; A J Cedarbaum; J C Reed
Journal:  Science       Date:  1986-11-28       Impact factor: 47.728

2.  Recovery of AIDS-associated retroviruses from patients with AIDS or AIDS-related conditions and from clinically healthy individuals.

Authors:  J A Levy; J Shimabukuro
Journal:  J Infect Dis       Date:  1985-10       Impact factor: 5.226

3.  CD4 is not the membrane receptor for HHV-6.

Authors:  P Lusso; R C Gallo; S E DeRocco; P D Markham
Journal:  Lancet       Date:  1989-04-01       Impact factor: 79.321

4.  Transactivation of human immunodeficiency virus promoter by human herpesvirus 6.

Authors:  R T Horvat; C Wood; N Balachandran
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

5.  Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6.

Authors:  P Lusso; B Ensoli; P D Markham; D V Ablashi; S Z Salahuddin; E Tschachler; F Wong-Staal; R C Gallo
Journal:  Nature       Date:  1989-01-26       Impact factor: 49.962

6.  Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines.

Authors:  L Montagnier; J Gruest; S Chamaret; C Dauguet; C Axler; D Guétard; M T Nugeyre; F Barré-Sinoussi; J C Chermann; J B Brunet
Journal:  Science       Date:  1984-07-06       Impact factor: 47.728

7.  Indirect immunofluorescence assay for antibodies to human immunodeficiency virus.

Authors:  E T Lennette; S Karpatkin; J A Levy
Journal:  J Clin Microbiol       Date:  1987-02       Impact factor: 5.948

8.  Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions.

Authors:  A D Hoffman; B Banapour; J A Levy
Journal:  Virology       Date:  1985-12       Impact factor: 3.616

9.  Long-term cultivation of T-cell subsets from patients with acquired immune deficiency syndrome.

Authors:  J A Levy; L H Tobler; T M McHugh; C H Casavant; D P Stites
Journal:  Clin Immunol Immunopathol       Date:  1985-06

10.  CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication.

Authors:  C M Walker; D J Moody; D P Stites; J A Levy
Journal:  Science       Date:  1986-12-19       Impact factor: 47.728
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  17 in total

Review 1.  Human herpesvirus 6.

Authors:  D K Braun; G Dominguez; P E Pellett
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

2.  Interactions between opportunistic micro-organisms and HIV in the lung.

Authors:  J R Clarke; D Israel-Biet
Journal:  Thorax       Date:  1996-09       Impact factor: 9.139

3.  Inhibition of human immunodeficiency virus type 1 replication prior to reverse transcription by influenza virus stimulation.

Authors:  L A Pinto; V Blazevic; B K Patterson; C Mac Trubey; M J Dolan; G M Shearer
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

Review 4.  Update on human herpesvirus 6 biology, clinical features, and therapy.

Authors:  Leen De Bolle; Lieve Naesens; Erik De Clercq
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

5.  Human herpesvirus 6 infects dendritic cells and suppresses human immunodeficiency virus type 1 replication in coinfected cultures.

Authors:  H Asada; V Klaus-Kovtun; H Golding; S I Katz; A Blauvelt
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

6.  Identification and characterization of a human herpesvirus 6 gene segment capable of transactivating the human immunodeficiency virus type 1 long terminal repeat in an Sp1 binding site-dependent manner.

Authors:  J Wang; C Jones; M Norcross; E Bohnlein; A Razzaque
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

Review 7.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03

8.  Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses.

Authors:  V Koval; C Clark; M Vaishnav; S A Spector; D H Spector
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

9.  Identification of the human herpesvirus 6 glycoprotein H and putative large tegument protein genes.

Authors:  S F Josephs; D V Ablashi; S Z Salahuddin; L L Jagodzinski; F Wong-Staal; R C Gallo
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

10.  Structure and transcription of an immediate-early region in the human herpesvirus 6 genome.

Authors:  U Schiewe; F Neipel; D Schreiner; B Fleckenstein
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103
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