Literature DB >> 6328661

Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines.

L Montagnier, J Gruest, S Chamaret, C Dauguet, C Axler, D Guétard, M T Nugeyre, F Barré-Sinoussi, J C Chermann, J B Brunet.   

Abstract

A strain of lymphadenopathy associated retrovirus ( LAV ) passaged in vitro was used to infect a lymphoblastoid cell line obtained by transformation with Epstein-Barr virus of B lymphocytes from a healthy donor. The virus produced from this line (B- LAV ) was also able to grow at a high rate in some other lymphoblastoid lines and in a Burkitt lymphoma line. This adapted strain retained the biochemical, ultrastructural, and antigenic characteristics of the original strain, as well as its tropism for normal T4+ lymphocytes. It is thus possible to grow LAV in large quantities that can be used for the preparation of diagnostic reagents. The interaction between such a human retrovirus and Epstein-Barr virus, a DNA virus, may have some implication for the pathology of the acquired immunodeficiency syndrome and related diseases.

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Year:  1984        PMID： 6328661     DOI： 10.1126/science.6328661

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  68 in total

1.  Human immunodeficiency virus and related retroviruses.

Authors:  R Nájera; M I Herrera; R de Andrés
Journal:  West J Med       Date:  1987-12

2.  High frequency of isolation of defective human immunodeficiency virus type 1 and heterogeneity of viral gene expression in clones of infected U-937 cells.

Authors:  F Boulerice; S Bour; R Geleziunas; A Lvovich; M A Wainberg
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

3.  Activity of soluble factors produced by Epstein-Barr virus-transformed human B lymphocytes on different cell lines.

Authors:  C Garzelli; A Bazzichi
Journal:  Experientia       Date:  1991-07-15

4.  α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide.

Authors:  Mauricio Urquiza; Johanna Melo-Cardenas; Tatiana Guevara; Ignacia Echeverria; Isabel C Rodriguez; Magnolia Vanegas; Mario Amzel; Manuel E Patarroyo
Journal:  Amino Acids       Date:  2010-05-16       Impact factor: 3.520

5.  Studies on human immunodeficiency virus-induced cytopathic effects: use of human rhabdomyosarcoma (RD) cells.

Authors:  A Srinivasan; C S Goldsmith; D York; R Anand; P Luciw; G Schochetman; E Palmer; C Bohan
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

6.  Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

Authors:  A Adachi; H E Gendelman; S Koenig; T Folks; R Willey; A Rabson; M A Martin
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

7.  B-cell activation in HIV infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters.

Authors:  H Mizuma; S Litwin; S Zolla-Pazner
Journal:  Clin Exp Immunol       Date:  1988-03       Impact factor: 4.330

8.  In vivo lymphocyte tropism of feline immunodeficiency virus.

Authors:  R V English; C M Johnson; D H Gebhard; M B Tompkins
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

9.  Evaluation of human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte responses utilizing B-lymphoblastoid cell lines transduced with the CD4 gene and infected with HIV-1.

Authors:  M J McElrath; M Rabin; M Hoffman; S Klucking; J V Garcia; P D Greenberg
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

10.  Expression of a human immunodeficiency virus type 1 long terminal repeat/simian virus 40 early region fusion gene in transgenic mice.

Authors:  J Skowronski
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103
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