Literature DB >> 21715177

Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.

Doralyn S Dalisay1, Jonel P Saludes, Tadeusz F Molinski.   

Abstract

The antifungal spirocyclic guanidine alkaloid, ptilomycalin A, from marine sponge Monanchora arbuscula, inhibits melanogenesis of Cryptococcus neoformans in vitro through inhibition of biosynthesis of laccase in the melanin biosynthetic pathway with an IC(50) of 7.3 μM.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21715177      PMCID： PMC3523195          DOI： 10.1016/j.bmc.2011.05.041

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  29 in total

1.  The changing epidemiology of cryptococcosis: an update from population-based active surveillance in 2 large metropolitan areas, 1992-2000.

Authors:  Sara A Mirza; Maureen Phelan; David Rimland; Edward Graviss; Richard Hamill; Mary E Brandt; Tracie Gardner; Matthew Sattah; Gabriel Ponce de Leon; Wendy Baughman; Rana A Hajjeh
Journal:  Clin Infect Dis       Date:  2003-02-27       Impact factor: 9.079

2.  Antifungal activity of amphotericin B-lipid admixtures in experimental systemic candidosis in naive mice.

Authors:  Y Shadkchan; E Segal
Journal:  J Antimicrob Chemother       Date:  1999-12       Impact factor: 5.790

3.  Inhibition of laccase activity from Trametes versicolor by heavy metals and organic compounds.

Authors:  M Lorenzo; D Moldes; S Rodríguez Couto; Maria A Sanromán
Journal:  Chemosphere       Date:  2005-08       Impact factor: 7.086

4.  The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase.

Authors:  H C Steinrücken; N Amrhein
Journal:  Biochem Biophys Res Commun       Date:  1980-06-30       Impact factor: 3.575

5.  Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin.

Authors:  David van Duin; Arturo Casadevall; Joshua D Nosanchuk
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

6.  Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor.

Authors:  X Zhu; J Gibbons; J Garcia-Rivera; A Casadevall; P R Williamson
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

7.  Laccase and melanization in clinically important Cryptococcus species other than Cryptococcus neoformans.

Authors:  Reiko Ikeda; Takashi Sugita; Eric S Jacobson; Takako Shinoda
Journal:  J Clin Microbiol       Date:  2002-04       Impact factor: 5.948

8.  Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans.

Authors:  C A Hitchcock; K Dickinson; S B Brown; E G Evans; D J Adams
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

9.  Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase.

Authors:  P R Williamson
Journal:  J Bacteriol       Date:  1994-02       Impact factor: 3.490

10.  Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.

Authors:  Y Wang; A Casadevall
Journal:  Infect Immun       Date:  1994-07       Impact factor: 3.441
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  3 in total

Review 1.  Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas.

Authors:  Amr El-Demerdash; Atanas G Atanasov; Anupam Bishayee; Mamdouh Abdel-Mogib; John N A Hooper; Ali Al-Mourabit
Journal:  Nutrients       Date:  2018-01-02       Impact factor: 5.717

2.  Synthesis and Structure-Activity Relationship Studies of Hydrazide-Hydrazones as Inhibitors of Laccase from Trametes versicolor.

Authors:  Halina Maniak; Michał Talma; Konrad Matyja; Anna Trusek; Mirosław Giurg
Journal:  Molecules       Date:  2020-03-10       Impact factor: 4.411

3.  Inhibitory Potential of New Phenolic Hydrazide-Hydrazones with a Decoy Substrate Fragment towards Laccase from a Phytopathogenic Fungus: SAR and Molecular Docking Studies.

Authors:  Halina Maniak; Michał Talma; Mirosław Giurg
Journal:  Int J Mol Sci       Date:  2021-11-14       Impact factor: 5.923
  3 in total

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