OBJECTIVES: The purpose of this study was to determine the sensitivity of breast-specific gamma imaging (BSGI) in the detection of invasive breast cancers and to characterise the sensitivity of BSGI based on tumour size and pathological grade. METHODS: 139 females with invasive carcinoma who underwent BSGI were retrospectively reviewed. Patients were injected in the antecubital vein with 20-30 mCi (925-1110 MBq) of (99m)Tc-sestamibi. Images were obtained with a high-resolution, breast-specific gamma camera (Dilon 6800; Dilon Technologies, Newport News, VA) and were categorised based on radiotracer uptake as normal, normal with heterogeneous uptake, probably abnormal and abnormal. For a positive examination, the region of the area of increased uptake had to correlate with the laterality and location of the biopsy-proven cancer. RESULTS: 149 invasive cancers in 139 patients with a mean size of 1.8 cm (0.2-8.5 cm) were included. 146 were identified with BSGI (98.0%). All cancers which measured ≥ 0.7 cm (n = 123) as well as all cancers grade 2 or higher (n = 102), regardless of tumour size, were identified with BSGI (100%). There were 6 cancers that were pathological grade 1 and measured <7 mm, of which 50% (3/6) were identified with BSGI. The overall sensitivity of BSGI for the detection of invasive breast cancer is 98.0%. The sensitivity for subcentimetre cancers is 88.5% (23/26). CONCLUSION: BSGI has a high sensitivity for the detection of invasive breast cancer. Our results demonstrate that BSGI detected all invasive breast cancers pathological grade 2 and higher regardless of size and all cancers which measured ≥ 7 mm regardless of grade. BSGI can reliably detect invasive breast cancers and is a useful adjunct imaging modality for the diagnosis of breast cancer.
OBJECTIVES: The purpose of this study was to determine the sensitivity of breast-specific gamma imaging (BSGI) in the detection of invasive breast cancers and to characterise the sensitivity of BSGI based on tumour size and pathological grade. METHODS: 139 females with invasive carcinoma who underwent BSGI were retrospectively reviewed. Patients were injected in the antecubital vein with 20-30 mCi (925-1110 MBq) of (99m)Tc-sestamibi. Images were obtained with a high-resolution, breast-specific gamma camera (Dilon 6800; Dilon Technologies, Newport News, VA) and were categorised based on radiotracer uptake as normal, normal with heterogeneous uptake, probably abnormal and abnormal. For a positive examination, the region of the area of increased uptake had to correlate with the laterality and location of the biopsy-proven cancer. RESULTS: 149 invasive cancers in 139 patients with a mean size of 1.8 cm (0.2-8.5 cm) were included. 146 were identified with BSGI (98.0%). All cancers which measured ≥ 0.7 cm (n = 123) as well as all cancers grade 2 or higher (n = 102), regardless of tumour size, were identified with BSGI (100%). There were 6 cancers that were pathological grade 1 and measured <7 mm, of which 50% (3/6) were identified with BSGI. The overall sensitivity of BSGI for the detection of invasive breast cancer is 98.0%. The sensitivity for subcentimetre cancers is 88.5% (23/26). CONCLUSION: BSGI has a high sensitivity for the detection of invasive breast cancer. Our results demonstrate that BSGI detected all invasive breast cancers pathological grade 2 and higher regardless of size and all cancers which measured ≥ 7 mm regardless of grade. BSGI can reliably detect invasive breast cancers and is a useful adjunct imaging modality for the diagnosis of breast cancer.
Authors: Rachel F Brem; Joelle M Schoonjans; Douglas A Kieper; Stan Majewski; Steven Goodman; Cahid Civelek Journal: J Nucl Med Date: 2002-07 Impact factor: 10.057
Authors: Rachel F Brem; Ivan Petrovitch; Jocelyn A Rapelyea; Heather Young; Christine Teal; Tricia Kelly Journal: Breast J Date: 2007 Sep-Oct Impact factor: 2.431
Authors: I Khalkhali; J A Cutrone; I G Mena; L E Diggles; R J Venegas; H I Vargas; B L Jackson; S Khalkhali; J F Moss; S R Klein Journal: Radiology Date: 1995-08 Impact factor: 11.105
Authors: R D Rosenberg; W C Hunt; M R Williamson; F D Gilliland; P W Wiest; C A Kelsey; C R Key; M N Linver Journal: Radiology Date: 1998-11 Impact factor: 11.105
Authors: Rachel F Brem; Marina Ioffe; Jocelyn A Rapelyea; Kristen G Yost; Jean M Weigert; Margaret L Bertrand; Lillian H Stern Journal: AJR Am J Roentgenol Date: 2009-02 Impact factor: 3.959
Authors: T Meissnitzer; A Seymer; P Keinrath; J Holzmannhofer; C Pirich; K Hergan; M W Meissnitzer Journal: Br J Radiol Date: 2015-04-17 Impact factor: 3.039
Authors: Amy Lynn Conners; Katie N Jones; Carrie B Hruska; Jennifer R Geske; Judy C Boughey; Deborah J Rhodes Journal: AJR Am J Roentgenol Date: 2015-09 Impact factor: 3.959