Literature DB >> 21681694

Oncogene-induced senescence and its role in tumor suppression.

Jay P Reddy1, Yi Li.   

Abstract

While senescence has been known for some time as an inevitable result of repeated DNA replication, oncogene-induced senescence (OIS) represents a relatively new phenomenon. OIS, like apoptosis, has emerged to represent a putative barrier to tumorigenesis in many tissues, including the breast. Here we discuss signals that initiate OIS, evidence for its role in tumor suppression, and mechanisms for its evasion in tumorigenesis.

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Year:  2011        PMID： 21681694     DOI： 10.1007/s10911-011-9221-5

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  93 in total

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5.  Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

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6.  A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.

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Journal:  Nature       Date:  1990-05-31       Impact factor: 49.962

9.  Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

Authors:  Kimi Yamakoshi; Akiko Takahashi; Fumiko Hirota; Rika Nakayama; Naozumi Ishimaru; Yoshiaki Kubo; David J Mann; Masako Ohmura; Atsushi Hirao; Hideyuki Saya; Seiji Arase; Yoshio Hayashi; Kazuki Nakao; Mitsuru Matsumoto; Naoko Ohtani; Eiji Hara
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Review 10.  A role for CXCR2 in senescence, but what about in cancer?

Authors:  Juan C Acosta; Jesús Gil
Journal:  Cancer Res       Date:  2009-03-10       Impact factor: 12.701
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  9 in total

1.  A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis.

Authors:  Vidya C Sinha; Lan Qin; Yi Li
Journal:  Mol Cancer Res       Date:  2014-09-24       Impact factor: 5.852

2.  Intraductal Injection of Lentivirus Vectors for Stably Introducing Genes into Rat Mammary Epithelial Cells in Vivo.

Authors:  Wen Bu; Yi Li
Journal:  J Mammary Gland Biol Neoplasia       Date:  2020-11-09       Impact factor: 2.673

3.  [Characteristics of aging skin].

Authors:  J Wohlrab; K Hilpert; A Wohlrab
Journal:  Hautarzt       Date:  2014-10       Impact factor: 0.751

Review 4.  Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy.

Authors:  Chaido Sirinian; Stavros Peroukidis; Katharina Kriegsmann; Dimitrios Chaniotis; Angelos Koutras; Mark Kriegsmann; Anastasios D Papanastasiou
Journal:  Genes (Basel)       Date:  2022-06-01       Impact factor: 4.141

Review 5.  Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Authors:  Guillaume Bergthold; Pratiti Bandopadhayay; Wenya Linda Bi; Lori Ramkissoon; Charles Stiles; Rosalind A Segal; Rameen Beroukhim; Keith L Ligon; Jacques Grill; Mark W Kieran
Journal:  Biochim Biophys Acta       Date:  2014-02-28

6.  HiJAK'd Signaling; the STAT3 Paradox in Senescence and Cancer Progression.

Authors:  Damian J Junk; Benjamin L Bryson; Mark W Jackson
Journal:  Cancers (Basel)       Date:  2014-03-26       Impact factor: 6.639

7.  Oncodriver inhibition and CD4+ Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies.

Authors:  Cinthia Rosemblit; Jashodeep Datta; Lea Lowenfeld; Shuwen Xu; Amrita Basu; Krithika Kodumudi; Doris Wiener; Brian J Czerniecki
Journal:  Oncotarget       Date:  2018-05-01

8.  Integrated TCGA analysis implicates lncRNA CTB-193M12.5 as a prognostic factor in lung adenocarcinoma.

Authors:  Xuehai Wang; Gang Li; Qingsong Luo; Jiayong Xie; Chongzhi Gan
Journal:  Cancer Cell Int       Date:  2018-02-22       Impact factor: 5.722

Review 9.  HSP70s in Breast Cancer: Promoters of Tumorigenesis and Potential Targets/Tools for Therapy.

Authors:  Alexander E Kabakov; Vladimir L Gabai
Journal:  Cells       Date:  2021-12-07       Impact factor: 6.600
  9 in total

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