Literature DB >> 21657201

Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.

Alexey V Tkach1, Galina V Shurin, Michael R Shurin, Elena R Kisin, Ashley R Murray, Shih-Houng Young, Alexander Star, Bengt Fadeel, Valerian E Kagan, Anna A Shvedova.   

Abstract

Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.

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Year:  2011        PMID： 21657201      PMCID： PMC3170729          DOI： 10.1021/nn2014479

Source DB:  PubMed          Journal:  ACS Nano        ISSN： 1936-0851            Impact factor:   15.881


  50 in total

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Review 9.  IDO expression by dendritic cells: tolerance and tryptophan catabolism.

Authors:  Andrew L Mellor; David H Munn
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10.  Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.

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  39 in total

1.  Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo.

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Journal:  Nanomedicine (Lond)       Date:  2012-05-25       Impact factor: 5.307

Review 2.  Nanoparticles and direct immunosuppression.

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Journal:  Exp Biol Med (Maywood)       Date:  2016-05

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Journal:  Acc Chem Res       Date:  2012-07-23       Impact factor: 22.384

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Authors:  Gregg P Kotchey; James A Gaugler; Alexander A Kapralov; Valerian E Kagan; Alexander Star
Journal:  J Mater Chem B       Date:  2013       Impact factor: 6.331

5.  Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.

Authors:  Anna A Shvedova; Alexey V Tkach; Elena R Kisin; Timur Khaliullin; Shyla Stanley; Dmitriy W Gutkin; Alexander Star; Yanan Chen; Galina V Shurin; Valerian E Kagan; Michael R Shurin
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Review 6.  Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?

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Review 7.  Perturbation of pulmonary immune functions by carbon nanotubes and susceptibility to microbial infection.

Authors:  Brent E Walling; Gee W Lau
Journal:  J Microbiol       Date:  2014-03-01       Impact factor: 3.422

Review 8.  From immunotoxicity to nanotherapy: the effects of nanomaterials on the immune system.

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Journal:  Toxicol Sci       Date:  2014-01-15       Impact factor: 4.849

9.  Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.

Authors:  Alexey V Tkach; Naveena Yanamala; Shyla Stanley; Michael R Shurin; Galina V Shurin; Elena R Kisin; Ashley R Murray; Samantha Pareso; Timur Khaliullin; Gregg P Kotchey; Vincent Castranova; Sanjay Mathur; Bengt Fadeel; Alexander Star; Valerian E Kagan; Anna A Shvedova
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Authors:  Naveena Yanamala; Valerian E Kagan; Anna A Shvedova
Journal:  Adv Drug Deliv Rev       Date:  2013-05-28       Impact factor: 15.470
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