| Literature DB >> 12228717 |
David H Munn1, Madhav D Sharma, Jeffrey R Lee, Kanchan G Jhaver, Theodore S Johnson, Derin B Keskin, Brendan Marshall, Phillip Chandler, Scott J Antonia, Russell Burgess, Craig L Slingluff, Andrew L Mellor.
Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.Entities:
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Year: 2002 PMID： 12228717 DOI： 10.1126/science.1073514
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728