| Literature DB >> 14639467 |
Masato Kubo1, Toshikatsu Hanada, Akihiko Yoshimura.
Abstract
The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.Entities:
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Year: 2003 PMID: 14639467 DOI: 10.1038/ni1012
Source DB: PubMed Journal: Nat Immunol ISSN: 1529-2908 Impact factor: 25.606