| Literature DB >> 22887961 |
Alexey V Tkach1, Naveena Yanamala, Shyla Stanley, Michael R Shurin, Galina V Shurin, Elena R Kisin, Ashley R Murray, Samantha Pareso, Timur Khaliullin, Gregg P Kotchey, Vincent Castranova, Sanjay Mathur, Bengt Fadeel, Alexander Star, Valerian E Kagan, Anna A Shvedova.
Abstract
Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.Entities:
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Year: 2012 PMID： 22887961 PMCID： PMC4009732 DOI： 10.1002/smll.201201546
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281