Literature DB >> 21649648

Antibody fragments as tools in crystallography.

L Griffin1, A Lawson.   

Abstract

While antibody-based therapeutics have become firmly established as front-line drugs, the use of antibodies as research tools in small molecule drug discovery is still in its infancy. In this review we focus on the use of antibody fragments as crystallization chaperones to aid the structural determination of otherwise 'uncrystallizable' or 'undruggable' target proteins. We also highlight a potential application for this technology, in which antibody-mediated structures may be used to inform the design of new chemical entities.
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.

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Year:  2011        PMID： 21649648      PMCID： PMC3170977          DOI： 10.1111/j.1365-2249.2011.04427.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  58 in total

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Authors:  Erwin J De Genst; Tim Guilliams; Joke Wellens; Elizabeth M O'Day; Christopher A Waudby; Sarah Meehan; Mireille Dumoulin; Shang-Te Danny Hsu; Nunilo Cremades; Koen H G Verschueren; Els Pardon; Lode Wyns; Jan Steyaert; John Christodoulou; Christopher M Dobson
Journal:  J Mol Biol       Date:  2010-07-08       Impact factor: 5.469

2.  Conversion of scFv peptide-binding specificity for crystal chaperone development.

Authors:  Jennifer C Pai; Jeffrey A Culver; Jason E Drury; Rakesh S Motani; Raquel L Lieberman; Jennifer A Maynard
Journal:  Protein Eng Des Sel       Date:  2011-01-08       Impact factor: 1.650

3.  Crystal structure of full-length KcsA in its closed conformation.

Authors:  Serdar Uysal; Valeria Vásquez; Valentina Tereshko; Kaori Esaki; Frederic A Fellouse; Sachdev S Sidhu; Shohei Koide; Eduardo Perozo; Anthony Kossiakoff
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-03       Impact factor: 11.205

4.  DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding.

Authors:  Olivera Grubisha; Monika Kaminska; Stéphane Duquerroy; Elisabeth Fontan; Florence Cordier; Ahmed Haouz; Bertrand Raynal; Jeanne Chiaravalli; Muriel Delepierre; Alain Israël; Michel Véron; Fabrice Agou
Journal:  J Mol Biol       Date:  2009-10-23       Impact factor: 5.469

5.  Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.

Authors:  C Hunte; J Koepke; C Lange; T Rossmanith; H Michel
Journal:  Structure       Date:  2000-06-15       Impact factor: 5.006

6.  Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.

Authors:  Katarzyna Domanska; Saskia Vanderhaegen; Vasundara Srinivasan; Els Pardon; Florine Dupeux; Jose A Marquez; Sofia Giorgetti; Monica Stoppini; Lode Wyns; Vittorio Bellotti; Jan Steyaert
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-10       Impact factor: 11.205

7.  Fusion protein approach to improve the crystal quality of cytochrome bo(3) ubiquinol oxidase from Escherichia coli.

Authors:  B Byrne; J Abramson; M Jansson; E Holmgren; S Iwata
Journal:  Biochim Biophys Acta       Date:  2000-08-15

8.  Structural basis for high-affinity HER2 receptor binding by an engineered protein.

Authors:  Charles Eigenbrot; Mark Ultsch; Anatoly Dubnovitsky; Lars Abrahmsén; Torleif Härd
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-09       Impact factor: 11.205

9.  Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

Authors:  Søren G F Rasmussen; Hee-Jung Choi; Juan Jose Fung; Els Pardon; Paola Casarosa; Pil Seok Chae; Brian T Devree; Daniel M Rosenbaum; Foon Sun Thian; Tong Sun Kobilka; Andreas Schnapp; Ingo Konetzki; Roger K Sunahara; Samuel H Gellman; Alexander Pautsch; Jan Steyaert; William I Weis; Brian K Kobilka
Journal:  Nature       Date:  2011-01-13       Impact factor: 49.962

Review 10.  Engineering of recombinant crystallization chaperones.

Authors:  Shohei Koide
Journal:  Curr Opin Struct Biol       Date:  2009-05-26       Impact factor: 6.809
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  26 in total

Review 1.  Membrane proteins, detergents and crystals: what is the state of the art?

Authors:  Patrick J Loll
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-11-28       Impact factor: 1.056

Review 2.  Can the propensity of protein crystallization be increased by using systematic screening with metals?

Authors:  Raghurama P Hegde; Gowribidanur C Pavithra; Debayan Dey; Steven C Almo; S Ramakumar; Udupi A Ramagopal
Journal:  Protein Sci       Date:  2017-06-29       Impact factor: 6.725

3.  Application of the NZ-1 Fab as a crystallization chaperone for PA tag-inserted target proteins.

Authors:  Risako Tamura; Rika Oi; Satoko Akashi; Mika K Kaneko; Yukinari Kato; Terukazu Nogi
Journal:  Protein Sci       Date:  2019-02-04       Impact factor: 6.725

4.  Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.

Authors:  Jian Sun; Marcin Paduch; Sang-Ah Kim; Ryan M Kramer; Adam F Barrios; Vincent Lu; Judy Luke; Svitlana Usatyuk; Anthony A Kossiakoff; Song Tan
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-17       Impact factor: 11.205

5.  Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy.

Authors:  Derek P Claxton; Kelli Kazmier; Smriti Mishra; Hassane S Mchaourab
Journal:  Methods Enzymol       Date:  2015-08-29       Impact factor: 1.600

6.  The intervening removable affinity tag (iRAT) production system facilitates Fv antibody fragment-mediated crystallography.

Authors:  Yayoi Nomura; Yumi Sato; Ryoji Suno; Shoichiro Horita; So Iwata; Norimichi Nomura
Journal:  Protein Sci       Date:  2016-09-14       Impact factor: 6.725

7.  Structural and biophysical characterizations of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly.

Authors:  R Elliot Murphy; Alexandra B Samal; Jiri Vlach; Vicente Mas; Peter E Prevelige; Jamil S Saad
Journal:  J Biol Chem       Date:  2019-10-22       Impact factor: 5.157

8.  Enhancing ubiquitin crystallization through surface-entropy reduction.

Authors:  Patrick J Loll; Peining Xu; John T Schmidt; Scott L Melideo
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-09-25       Impact factor: 1.056

9.  Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.

Authors:  Callum F Lawrence; Mai B Margetts; John G Menting; Nicholas A Smith; Brian J Smith; Colin W Ward; Michael C Lawrence
Journal:  J Biol Chem       Date:  2016-06-08       Impact factor: 5.157

10.  Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.

Authors:  Elif Eren; Norman R Watts; Altaira D Dearborn; Ira W Palmer; Joshua D Kaufman; Alasdair C Steven; Paul T Wingfield
Journal:  Structure       Date:  2018-08-09       Impact factor: 5.006
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