Literature DB >> 21621273

Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

Małgorzata Wrzosek1, Jacek Łukaszkiewicz, Michał Wrzosek, Piotr Serafin, Andrzej Jakubczyk, Anna Klimkiewicz, Halina Matsumoto, Kirk J Brower, Marcin Wojnar.   

Abstract

We investigated a relationship between selected polymorphisms: rs6313 in HTR2A, rs6295 in HTR1A and rs1386494 in TPH2, and suicidal behaviour in 150 alcohol-dependent patients. There was a significant association between more frequent C102C genotype in HTR2A and suicide attempts in alcoholic females. No differences in genotype distribution in HTR1A and TPH2 SNPs were found between patients with and without suicide attempts.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21621273      PMCID： PMC3169703          DOI： 10.1016/j.psychres.2011.04.027

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  25 in total

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