INTRODUCTION: Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE: In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. METHODS: The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sample, composed of 64 mood disorder patients (35.9% males, mean age: 43.0+/-14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered. RESULTS: Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. CONCLUSIONS: Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.
INTRODUCTION:Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE: In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. METHODS: The SNPs considered were, for HTR1Ars1423691, rs878567 and rs6295, and for HTR2Crs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatricpatient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sample, composed of 64 mood disorderpatients (35.9% males, mean age: 43.0+/-14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1Ars6295 and the HTR2Crs6318 SNPs were considered. RESULTS: Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. CONCLUSIONS: Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorderpatients.
Authors: Małgorzata Wrzosek; Jacek Łukaszkiewicz; Michał Wrzosek; Piotr Serafin; Andrzej Jakubczyk; Anna Klimkiewicz; Halina Matsumoto; Kirk J Brower; Marcin Wojnar Journal: Psychiatry Res Date: 2011-05-31 Impact factor: 3.222
Authors: Vasileios Boulougouris; Ioannis Malogiannis; George Lockwood; Iannis Zervas; Giuseppe Di Giovanni Journal: Exp Brain Res Date: 2013-08-23 Impact factor: 1.972
Authors: Gabriel Molina-Guzman; Thelma Beatriz González-Castro; Yazmín Hernández Díaz; Carlos Alfonso Tovilla-Zárate; Isela E Juárez-Rojop; Crystell Guadalupe Guzmán-Priego; Alma Genis; Sherezada Pool García; María Lilia López-Narvaez; José Manuel Rodriguez-Perez Journal: Neuropsychiatr Dis Treat Date: 2017-02-22 Impact factor: 2.570
Authors: Marta Sadkowski; Brittany Dennis; Robert C Clayden; Wala Elsheikh; Sumathy Rangarajan; Jane Dejesus; Zainab Samaan Journal: Neuropsychiatr Dis Treat Date: 2013-11-06 Impact factor: 2.570