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Literature DB >> 21587833

2-Chloro-N-(4-sulfamoylphen-yl)acetamide.

Mehmet Akkurt, Serife Pınar Yalçın, Hasan Türkmen, Orhan Büyükgüngör.

Abstract

In the title compound, C(8)H(9)ClN(2)O(3)S, the benzene ring makes a dihedral angle of 4.1 (9)° with the amido -NHCO- plane including the major occupancy component of the carbonyl O atom [19 (4)° for the minor component]. An intra-molecular C-H⋯O inter-action occurs. The O atom of the carbonyl group is disordered over two positions with site-occupancy factors of 0.67 (11) and 0.33 (11). Inter-molecular N-H⋯O hydrogen bonds help to stabilize the crystal structure.

Entities: Chemical Disease Species

Year: 2010 PMID： 21587833 PMCID： PMC3007016 DOI： 10.1107/S1600536810021185

Source DB: PubMed Journal: Acta Crystallogr Sect E Struct Rep Online ISSN： 1600-5368

6 in total

1. Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

Authors: Karen Köhler; Alexander Hillebrecht; Johannes Schulze Wischeler; Alessio Innocenti; Andreas Heine; Claudiu T Supuran; Gerhard Klebe
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

Review 2. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.

Authors: Claudiu T Supuran
Journal: Nat Rev Drug Discov Date: 2008-02 Impact factor: 84.694

3. A short history of SHELX.

Authors: George M Sheldrick
Journal: Acta Crystallogr A Date: 2007-12-21 Impact factor: 2.290

4. Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

Authors: Hasan Turkmen; Mustafa Durgun; Serpil Yilmaztekin; Mahmut Emul; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Journal: Bioorg Med Chem Lett Date: 2005-01-17 Impact factor: 2.823

Review 5. Anticonvulsant sulfonamides/sulfamates/sulfamides with carbonic anhydrase inhibitory activity: drug design and mechanism of action.

Authors: Anne Thiry; Jean-Michel Dogné; Claudiu T Supuran; Bernard Masereel
Journal: Curr Pharm Des Date: 2008 Impact factor: 3.116

6. Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.

Authors: Anna Ohradanova; Daniela Vullo; Juraj Kopacek; Claudia Temperini; Tatiana Betakova; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Journal: Biochem J Date: 2007-10-01 Impact factor: 3.857

6 in total

4 in total

2-Chloro-N-(4-sulfamoylphen-yl)acetamide.

1. Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

Review 2. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.

3. A short history of SHELX.

4. Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

Review 5. Anticonvulsant sulfonamides/sulfamates/sulfamides with carbonic anhydrase inhibitory activity: drug design and mechanism of action.

6. Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.

1. Crystal structure and Hirshfeld surface analysis of 2-chloro-N-(4-meth-oxy-phen-yl)acetamide.

2. N-Ethyl-N-(2-meth-oxy-phen-yl)benzene-sulfonamide.

3. 4-(5-Chloro-penta-namido)-benzene-sulfonamide.

4. 4-[3-(4-Methyl-piperidin-1-yl)propan-amido]-benzene-sulfonamide monohydrate.