Literature DB >> 21552393

IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.

S Todo1, L Makowka, T Starzl.   

Abstract

The immunosuppressive effects of FR 900506 were investigated for one month after canine kidney and liver transplantation. Eight untreated kidney recipients lived for 8 to 19 days, mean 12.1. In contrast, the one month survival of dogs given FR 900506 in daily oral doses of 0.5, 1.0, and 1.5 mg/kg was 2/6, 3/6, and 4/6 respectively. The one month survival of liver recipients was 4/5 compared to one month survival of 1/8 in historical untreated controls. There was no evidence from biochemical tests of hepatotoxicity or nephrotoxicity.

Entities:  

Year:  1987        PMID： 21552393      PMCID： PMC3089006     

Source DB:  PubMed          Journal:  Surg Res Commun        ISSN： 0882-9233


  5 in total

1.  Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat.

Authors:  T Ochiai; K Nakajima; M Nagata; T Suzuki; T Asano; T Uematsu; T Goto; S Hori; T Kenmochi; T Nakagoori
Journal:  Transplant Proc       Date:  1987-02       Impact factor: 1.066

Review 2.  Animal research in liver transplantation with special reference to the dog.

Authors:  S Todo; I Kam; S Lynch; T E Starzl
Journal:  Semin Liver Dis       Date:  1985-11       Impact factor: 6.115

3.  IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.

Authors:  A Zeevi; R Duquesnoy; G Eiras; S Todo; L Makowka; T Starzl
Journal:  Surg Res Commun       Date:  1987

4.  THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.

Authors:  P Lee; N Murase; S Todo; L Makowka; T Starzl
Journal:  Surg Res Commun       Date:  1987

5.  Canine liver transplantation under Nva2-cyclosporine versus cyclosporine.

Authors:  S Todo; K A Porter; I Kam; S Lynch; R Venkataramanan; A DeWolf; T E Starzl
Journal:  Transplantation       Date:  1986-03       Impact factor: 4.939
  5 in total
  6 in total

1.  In Vitro Immunosuppressive Effects of FK506 in Combination With Other Drugs.

Authors:  A Zeevi; R Duquesnoy; G Eiras; H Rabinowich; S Todo; L Makowka; T E Starzl
Journal:  Transplant Proc       Date:  1988-02-01       Impact factor: 1.066

2.  Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids.

Authors:  S Todo; A J Demetris; Y Ueda; O Imventarza; K Okuda; A Casavilla; S Cemaj; A Ghalab; V Mazzaferro; B S Rhoe
Journal:  Transplant Proc       Date:  1987-10       Impact factor: 1.066

3.  Effect of FK506 in experimental organ transplantation.

Authors:  S Todo; N Murase; Y Ueda; L Podesta; P ChapChap; D Kahn; K Okuda; O Imventarza; A Casavilla; J Demetris
Journal:  Transplant Proc       Date:  1988-02       Impact factor: 1.066

4.  Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A.

Authors:  A Zeevi; R Duquesnoy; G Eiras; H Rabinowich; S Todo; L Makowka; T E Starzl
Journal:  Transplant Proc       Date:  1987-10       Impact factor: 1.066

5.  Orthotopic liver transplantation in dogs receiving FK-506.

Authors:  S Todo; L Podesta; P ChapChap; D Kahn; C E Pan; Y Ueda; K Okuda; O Imventarza; A Casavilla; A J Demetris
Journal:  Transplant Proc       Date:  1987-10       Impact factor: 1.066

6.  IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.

Authors:  A Zeevi; R Duquesnoy; G Eiras; S Todo; L Makowka; T Starzl
Journal:  Surg Res Commun       Date:  1987
  6 in total

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