Literature DB >> 21552392

THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS.

P Lee1, N Murase, S Todo, L Makowka, T Starzl.   

Abstract

The immunosuppressive effects of FR 900506 were studied in Lewis rats given ACI heterotopic heart allografts. Intramuscular doses of 0.02 mg/kg daily for 2 weeks extended graft survival slightly, and with doses up to 1.28 mg/kg for 2 weeks, there is long-term graft survival. If only 3 daily doses were given starting on day 4 after transplantation, graft survival for almost 3 months was accomplished in 4 of 6 animals who still bear functioning hearts.

Entities:  

Year:  1987        PMID： 21552392      PMCID： PMC3089005     

Source DB:  PubMed          Journal:  Surg Res Commun        ISSN： 0882-9233


  3 in total

1.  Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat.

Authors:  T Ochiai; K Nakajima; M Nagata; T Suzuki; T Asano; T Uematsu; T Goto; S Hori; T Kenmochi; T Nakagoori
Journal:  Transplant Proc       Date:  1987-02       Impact factor: 1.066

2.  Improved technique of heart transplantation in rats.

Authors:  K Ono; E S Lindsey
Journal:  J Thorac Cardiovasc Surg       Date:  1969-02       Impact factor: 5.209

3.  Studies on the immunosuppressive properties of cyclosporin a in rats receiving renal allografts.

Authors:  W P Homan; J W Fabre; K A Williams; P R Millard; P J Morris
Journal:  Transplantation       Date:  1980-05       Impact factor: 4.939
  3 in total
  8 in total

1.  History of clinical transplantation.

Authors:  T E Starzl
Journal:  World J Surg       Date:  2000-07       Impact factor: 3.352

2.  In Vitro Immunosuppressive Effects of FK506 in Combination With Other Drugs.

Authors:  A Zeevi; R Duquesnoy; G Eiras; H Rabinowich; S Todo; L Makowka; T E Starzl
Journal:  Transplant Proc       Date:  1988-02-01       Impact factor: 1.066

3.  Effect of a single injection of high-dose FK506 on lung transplantation in rats.

Authors:  Y Sano; S Maruyama; M Aoe; H Date; N Shimizu
Journal:  Surg Today       Date:  1996       Impact factor: 2.549

4.  Effect of FK506 in experimental organ transplantation.

Authors:  S Todo; N Murase; Y Ueda; L Podesta; P ChapChap; D Kahn; K Okuda; O Imventarza; A Casavilla; J Demetris
Journal:  Transplant Proc       Date:  1988-02       Impact factor: 1.066

5.  New approaches in the use of cyclosporine: with particular reference to the liver.

Authors:  T E Starzl
Journal:  Transplant Proc       Date:  1988-06       Impact factor: 1.066

6.  IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.

Authors:  S Todo; L Makowka; T Starzl
Journal:  Surg Res Commun       Date:  1987-01-01

7.  IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.

Authors:  A Zeevi; R Duquesnoy; G Eiras; S Todo; L Makowka; T Starzl
Journal:  Surg Res Commun       Date:  1987

8.  Suppression of allograft rejection with FK506. I. Prolonged cardiac and liver survival in rats following short-course therapy.

Authors:  N Murase; D G Kim; S Todo; D V Cramer; J J Fung; T E Starzl
Journal:  Transplantation       Date:  1990-08       Impact factor: 4.939
  8 in total

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