| Literature DB >> 21550342 |
Anna K Stephan1, Maciej Kliszczak, Ciaran G Morrison.
Abstract
There exist three highly-conserved structural maintenance of chromosomes (Smc) complexes that ensure genome stability during eukaryotic cell division. There are the well-characterized cohesin and condensin complexes and the third Smc complex, Smc5/6. Nse2/Mms21, a SUMO ligase, is a component of the Smc5/6 complex and recent data have indicated that Nse1 may function as a ubiquitin ligase. Smc5/6 regulates sister chromatid cohesion, homologous recombination and chromatin structure and conformation. This review examines the functions of Smc5/6 in DNA repair and the maintenance of genomic integrity and explores the roles of the associated SUMO and ubiquitin ligases. Recent findings have indicated that Smc5/6 may play a topological role in chromosome dynamics, which may help understand the complexity of its activities.Entities:
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Year: 2011 PMID： 21550342 DOI： 10.1016/j.febslet.2011.04.067
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124