Literature DB >> 24269489

Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies.

Alexander R Ball1, Yen-Yun Chen1, Kyoko Yokomori2.   

Abstract

Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization. Cohesins mediate sister chromatid cohesion and cellular long-distance chromatin interactions affecting genome maintenance and gene expression. Discoveries of mutations in cohesin's subunits and its regulator proteins in human developmental disorders, so-called "cohesinopathies," reveal crucial roles for cohesins in development and cellular growth and differentiation. In this review, we discuss the latest findings concerning cohesin's functions in higher-order chromatin architecture organization and gene regulation and new insight gained from studies of cohesinopathies. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cohesin; Cohesinopathy; Cornelia de Lange Syndrome; NIPBL; Roberts' Syndrome

Mesh：

Substances：

Year:  2013        PMID： 24269489      PMCID： PMC3951616          DOI： 10.1016/j.bbagrm.2013.11.002

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  215 in total

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Authors:  Stephan Gruber; Christian H Haering; Kim Nasmyth
Journal:  Cell       Date:  2003-03-21       Impact factor: 41.582

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Journal:  Nat Struct Mol Biol       Date:  2003-12-29       Impact factor: 15.369

3.  Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells.

Authors:  Xiangduo Kong; Alexander R Ball; Eiichiro Sonoda; Jie Feng; Shunichi Takeda; Tatsuo Fukagawa; Tim J Yen; Kyoko Yokomori
Journal:  Mol Biol Cell       Date:  2008-12-30       Impact factor: 4.138

4.  CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

Authors:  Stephanie C Degner; Jiyoti Verma-Gaur; Timothy P Wong; Claudia Bossen; G Michael Iverson; Ali Torkamani; Christian Vettermann; Yin C Lin; Zhongliang Ju; Danae Schulz; Caroline S Murre; Barbara K Birshtein; Nicholas J Schork; Mark S Schlissel; Roy Riblet; Cornelis Murre; Ann J Feeney
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-23       Impact factor: 11.205

5.  ATP hydrolysis is required for cohesin's association with chromosomes.

Authors:  Prakash Arumugam; Stephan Gruber; Koichi Tanaka; Christian H Haering; Karl Mechtler; Kim Nasmyth
Journal:  Curr Biol       Date:  2003-11-11       Impact factor: 10.834

Review 6.  On the molecular etiology of Cornelia de Lange syndrome.

Authors:  Dale Dorsett; Ian D Krantz
Journal:  Ann N Y Acad Sci       Date:  2009-01       Impact factor: 5.691

7.  Systematic reduction of cohesin differentially affects chromosome segregation, condensation, and DNA repair.

Authors:  Jill M Heidinger-Pauli; Ozlem Mert; Carol Davenport; Vincent Guacci; Douglas Koshland
Journal:  Curr Biol       Date:  2010-05-06       Impact factor: 10.834

8.  Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.

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Journal:  PLoS Biol       Date:  2006-07       Impact factor: 8.029

9.  Cohesin relocation from sites of chromosomal loading to places of convergent transcription.

Authors:  Armelle Lengronne; Yuki Katou; Saori Mori; Shihori Yokobayashi; Gavin P Kelly; Takehiko Itoh; Yoshinori Watanabe; Katsuhiko Shirahige; Frank Uhlmann
Journal:  Nature       Date:  2004-06-30       Impact factor: 49.962

10.  NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome.

Authors:  Emma T Tonkin; Tzu-Jou Wang; Steven Lisgo; Michael J Bamshad; Tom Strachan
Journal:  Nat Genet       Date:  2004-05-16       Impact factor: 38.330
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  23 in total

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Authors:  Marlinde L van den Boogaard; Richard J F L Lemmers; Pilar Camaño; Patrick J van der Vliet; Nicol Voermans; Baziel G M van Engelen; Adolfo Lopez de Munain; Stephen J Tapscott; Nienke van der Stoep; Rabi Tawil; Silvère M van der Maarel
Journal:  Eur J Hum Genet       Date:  2015-03-18       Impact factor: 4.246

Review 2.  Disorders of Transcriptional Regulation: An Emerging Category of Multiple Malformation Syndromes.

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Journal:  Mol Syndromol       Date:  2016-09-02

3.  Measuring Sister Chromatid Cohesion Protein Genome Occupancy in Drosophila melanogaster by ChIP-seq.

Authors:  Dale Dorsett; Ziva Misulovin
Journal:  Methods Mol Biol       Date:  2017

Review 4.  Complex elaboration: making sense of meiotic cohesin dynamics.

Authors:  Susannah Rankin
Journal:  FEBS J       Date:  2015-05-09       Impact factor: 5.542

5.  Of mice, genes and aging.

Authors:  James DeGregori
Journal:  Haematologica       Date:  2020-01-31       Impact factor: 9.941

6.  A neural crest origin for cohesinopathy heart defects.

Authors:  Kevin Schuster; Bryony Leeke; Michael Meier; Yizhou Wang; Trent Newman; Sean Burgess; Julia A Horsfield
Journal:  Hum Mol Genet       Date:  2015-09-29       Impact factor: 6.150

7.  DNA Topoisomerase II modulates acetyl-regulation of cohesin-mediated chromosome dynamics.

Authors:  Su-Jiun Lin; Matthew J O'Connell
Journal:  Curr Genet       Date:  2017-04-05       Impact factor: 3.886

8.  PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation.

Authors:  Caitlin M Zuilkoski; Robert V Skibbens
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9.  The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells.

Authors:  Kuntal De; Pablo Bolaños-Villegas; Sayantan Mitra; Xiaohui Yang; Garret Homan; Guang-Yuh Jauh; Christopher A Makaroff
Journal:  Plant Cell       Date:  2016-01-26       Impact factor: 11.277

10.  De novo loss-of-function variants in STAG2 are associated with developmental delay, microcephaly, and congenital anomalies.

Authors:  Sureni V Mullegama; Steven D Klein; Milene V Mulatinho; Tharanga Niroshini Senaratne; Kathryn Singh; Dzung C Nguyen; Natalie M Gallant; Samuel P Strom; Shahnaz Ghahremani; Nagesh P Rao; Julian A Martinez-Agosto
Journal:  Am J Med Genet A       Date:  2017-03-11       Impact factor: 2.578
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