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Literature DB >> 27492969

The Arabidopsis SUMO E3 Ligase AtMMS21 Dissociates the E2Fa/DPa Complex in Cell Cycle Regulation.

Yiyang Liu¹, Jianbin Lai¹, Mengyuan Yu¹, Feige Wang¹, Juanjuan Zhang¹, Jieming Jiang¹, Huan Hu¹, Qian Wu¹, Guohui Lu¹, Panglian Xu¹, Chengwei Yang².

Abstract

Development requires the proper execution and regulation of the cell cycle via precise, conserved mechanisms. Critically, the E2F/DP complex controls the expression of essential genes during cell cycle transitions. Here, we discovered the molecular function of the Arabidopsis thaliana SUMO E3 ligase METHYL METHANESULFONATE SENSITIVITY GENE21 (AtMMS21) in regulating the cell cycle via the E2Fa/DPa pathway. DPa was identified as an AtMMS21-interacting protein and AtMMS21 competes with E2Fa for interaction with DPa. Moreover, DPa is a substrate for SUMOylation mediated by AtMMS21, and this SUMOylation enhances the dissociation of the E2Fa/DPa complex. AtMMS21 also affects the subcellular localization of E2Fa/DPa. The E2Fa/DPa target genes are upregulated in the root of mms21-1 and mms21-1 mutants showed increased endoreplication. Overexpression of DPa affected the root development of mms21-1, and overexpression of AtMMS21 completely recovered the abnormal phenotypes of 35S:E2Fa-DPa plants. Our results suggest that AtMMS21 dissociates the E2Fa/DPa complex via competition and SUMOylation in the regulation of plant cell cycle.

Entities: Chemical Gene Species

Year: 2016 PMID： 27492969 PMCID： PMC5059808 DOI： 10.1105/tpc.16.00439

Source DB: PubMed Journal: Plant Cell ISSN： 1040-4651 Impact factor: 11.277

63 in total

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Journal: Biochim Biophys Acta Date: 2012-08-10

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15 in total

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Journal: DNA Repair (Amst) Date: 2019-05-07

2. A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells.

Authors: Jieming Jiang; Ning Mao; Huan Hu; Jiahang Tang; Danlu Han; Song Liu; Qian Wu; Yiyang Liu; Changlian Peng; Jianbin Lai; Chengwei Yang
Journal: Proc Natl Acad Sci U S A Date: 2019-07-08 Impact factor: 11.205

3. The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.

Authors: Jianbin Lai; Jieming Jiang; Qian Wu; Ning Mao; Danlu Han; Huan Hu; Chengwei Yang
Journal: Plant Physiol Date: 2018-02-20 Impact factor: 8.340

4. The SUMO E3 Ligase SIZ1 Negatively Regulates Shoot Regeneration.

Authors: Duncan Coleman; Ayako Kawamura; Momoko Ikeuchi; David S Favero; Alice Lambolez; Bart Rymen; Akira Iwase; Takamasa Suzuki; Keiko Sugimoto
Journal: Plant Physiol Date: 2020-07-01 Impact factor: 8.340

5. Sumoylation of Turnip mosaic virus RNA Polymerase Promotes Viral Infection by Counteracting the Host NPR1-Mediated Immune Response.

Authors: Xiaofei Cheng; Ruyi Xiong; Yinzi Li; Fangfang Li; Xueping Zhou; Aiming Wang
Journal: Plant Cell Date: 2017-02-21 Impact factor: 11.277