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Literature DB >> 23328396

SUMO: a multifaceted modifier of chromatin structure and function.

Caelin Cubeñas-Potts¹, Michael J Matunis.

Abstract

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23328396 PMCID： PMC3555686 DOI： 10.1016/j.devcel.2012.11.020

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

136 in total

Review 1. Something about SUMO inhibits transcription.

Authors: Grace Gill
Journal: Curr Opin Genet Dev Date: 2005-10 Impact factor: 5.578

2. SUMO: the glue that binds.

Authors: Michael J Matunis; Xiang-Dong Zhang; Nathan A Ellis
Journal: Dev Cell Date: 2006-11 Impact factor: 12.270

3. The CTCF insulator protein is posttranslationally modified by SUMO.

Authors: Melissa J MacPherson; Linda G Beatty; Wenjing Zhou; Minjie Du; Paul D Sadowski
Journal: Mol Cell Biol Date: 2008-11-24 Impact factor: 4.272

4. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.

Authors: Che-Chang Chang; Mandar T Naik; Yen-Sung Huang; Jen-Chong Jeng; Pei-Hsin Liao; Hong-Yi Kuo; Chun-Chen Ho; Yung-Lin Hsieh; Chiou-Hong Lin; Nai-Jia Huang; Nandita M Naik; Camy C-H Kung; Shu-Yu Lin; Ruey-Hwa Chen; Kun-Sang Chang; Tai-Huang Huang; Hsiu-Ming Shih
Journal: Mol Cell Date: 2011-04-08 Impact factor: 17.970

5. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

Authors: Vittoria Matafora; Alfonsina D'Amato; Silvia Mori; Francesco Blasi; Angela Bachi
Journal: Mol Cell Proteomics Date: 2009-07-12 Impact factor: 5.911

6. SUMOylation regulates telomere length homeostasis by targeting Cdc13.

Authors: Lisa E Hang; Xianpeng Liu; Iris Cheung; Yan Yang; Xiaolan Zhao
Journal: Nat Struct Mol Biol Date: 2011-07-10 Impact factor: 15.369

7. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

Authors: Florence Y Lee; Emily J Faivre; Miyuki Suzawa; Erik Lontok; Daniel Ebert; Fang Cai; Denise D Belsham; Holly A Ingraham
Journal: Dev Cell Date: 2011-08-04 Impact factor: 12.270

8. Selective antegrade cerebral perfusion reduces brain injury following deep hypothermic circulatory arrest in the piglets' model by decreasing the levels of protein SUMO2/3-ylation.

Authors: Bin Li; Yaobin Zhu; Aijun Liu; Wei Lu; Junwu Su; Jing Zhang; Zhiqiang Li; Xiangming Fan; Yinglong Liu
Journal: Int J Clin Exp Med Date: 2014-11-15

Review 9. A conserved role for transcription factor sumoylation in binding-site selection.

Authors: Emanuel Rosonina
Journal: Curr Genet Date: 2019-05-15 Impact factor: 3.886

Review 10. SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes.

Authors: Xiaolan Zhao
Journal: Mol Cell Date: 2018-08-02 Impact factor: 17.970

SUMO: a multifaceted modifier of chromatin structure and function.

Review 1. Something about SUMO inhibits transcription.

2. SUMO: the glue that binds.

3. The CTCF insulator protein is posttranslationally modified by SUMO.

4. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.

5. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

6. SUMOylation regulates telomere length homeostasis by targeting Cdc13.

7. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

8. Covalent conjugation of Groucho with SUMO-1 modulates its corepressor activity.

9. A dynamic connection between centromeres and ND10 proteins.

10. Rad52 SUMOylation affects the efficiency of the DNA repair.

1. Identification of SUMO-2/3-modified proteins associated with mitotic chromosomes.

2. Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2.

Review 3. Regulation of transcription factor activity by interconnected post-translational modifications.

Review 4. SUMO rules: regulatory concepts and their implication in neurologic functions.

Review 5. PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation.

6. Atrx promotes heterochromatin formation at retrotransposons.

7. Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes.

8. Selective antegrade cerebral perfusion reduces brain injury following deep hypothermic circulatory arrest in the piglets' model by decreasing the levels of protein SUMO2/3-ylation.

Review 9. A conserved role for transcription factor sumoylation in binding-site selection.

Review 10. SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes.