Literature DB >> 21524577

Synthesis and properties of triazole-linked RNA.

Daniel Mutisya1, Chelliah Selvam, Scott D Kennedy, Eriks Rozners.   

Abstract

RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14°C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21524577      PMCID： PMC3099469          DOI： 10.1016/j.bmcl.2011.03.111

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

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Review 9.  Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.

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Review 10.  Aptamers Chemistry: Chemical Modifications and Conjugation Strategies.

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