Literature DB >> 15556399

RNA interference and chemically modified small interfering RNAs.

Muthiah Manoharan1.   

Abstract

RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine. The future success of this technology relies on identifying appropriate chemical modifications to improve stability, potency and in vivo cellular delivery. The present review summarizes the role of the chemist's toolbox in this emerging technology.

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Year:  2004        PMID： 15556399     DOI： 10.1016/j.cbpa.2004.10.007

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  82 in total

1.  Duplex end breathing determines serum stability and intracellular potency of siRNA-Au NPs.

Authors:  Pinal C Patel; Liangliang Hao; Weng Si Au Yeung; Chad A Mirkin
Journal:  Mol Pharm       Date:  2011-06-28       Impact factor: 4.939

2.  Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity.

Authors:  Olivia M Merkel; Meredith A Mintzer; Damiano Librizzi; Olga Samsonova; Tanja Dicke; Brian Sproat; Holger Garn; Peter J Barth; Eric E Simanek; Thomas Kissel
Journal:  Mol Pharm       Date:  2010-08-02       Impact factor: 4.939

3.  Monomers for preparation of amide linked RNA: Synthesis of C3'-homologated nucleoside amino acids from d-xylose.

Authors:  Paul Tanui; Martin Kullberg; Ni Song; Yashodhan Chivate; Eriks Rozners
Journal:  Tetrahedron       Date:  2010-07-01       Impact factor: 2.457

4.  Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

Authors:  Armando R Hernández; Larryn W Peterson; Eric T Kool
Journal:  ACS Chem Biol       Date:  2012-06-12       Impact factor: 5.100

5.  Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.

Authors:  Bryan A Kraynack; Brenda F Baker
Journal:  RNA       Date:  2005-11-21       Impact factor: 4.942

Review 6.  Silence of the transcripts: RNA interference in medicine.

Authors:  Sailen Barik
Journal:  J Mol Med (Berl)       Date:  2005-07-19       Impact factor: 4.599

7.  Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

Authors:  Katarzyna Sipa; Elzbieta Sochacka; Julia Kazmierczak-Baranska; Maria Maszewska; Magdalena Janicka; Genowefa Nowak; Barbara Nawrot
Journal:  RNA       Date:  2007-06-21       Impact factor: 4.942

8.  Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

Authors:  Uday Ghanty; Erik Fostvedt; Rachel Valenzuela; Peter A Beal; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

Review 9.  RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials.

Authors:  Eunice L Lozada-Delgado; Nilmary Grafals-Ruiz; Pablo E Vivas-Mejía
Journal:  Life Sci       Date:  2017-08-31       Impact factor: 5.037

10.  Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase.

Authors:  Carly A Shanahan; Barbara L Gaffney; Roger A Jones; Scott A Strobel
Journal:  Biochemistry       Date:  2013-01-03       Impact factor: 3.162
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