2,4-Bis(4-but-oxy-phen-yl)-3-aza-bicyclo-[3.3.1]nonan-9-one.

In the title compound, C(28)H(37)NO(3), a crystallographic mirror plane bis-ects the mol-ecule (one half-mol-ecule in the asymmetric unit). The title compound exists in a twin-chair conformation with an equatorial orientation of the 4-but-oxy-phenyl groups. Both sides of the secondary amino group carry the 4-but-oxy-phenyl groups at an angle of 38.54 (3)° with respect to one another.

Related literature

For the synthesis and biological activity of 3-aza­bicyclo­[3.3.1] nonan-9-ones, see: Jeyaraman & Avila (1981 ▶); Barker et al. (2005 ▶); Parthiban et al. (2009a ▶, 2010b ▶,c ▶); Cox et al. (1985 ▶). For related structures, see: Parthiban et al. (2009b ▶,c ▶, 2010a ▶); Smith-Verdier et al. (1983 ▶); Padegimas & Kovacic (1972 ▶). For ring puckering parameters, see: Cremer & Pople (1975 ▶); Nardelli (1983 ▶).

Experimental

Crystal data

C28H37NO3

M = 435.59

Orthorhombic,

a = 7.7780 (5) Å

b = 31.457 (2) Å

c = 9.9560 (6) Å

V = 2436.0 (3) Å3

Z = 4

Mo Kα radiation

μ = 0.08 mm−1

T = 298 K

0.35 × 0.28 × 0.25 mm

Data collection

Bruker APEXII CCD area-detector diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2004 ▶) T min = 0.974, T max = 0.981

10360 measured reflections

2991 independent reflections

1900 reflections with I > 2σ(I)

R int = 0.025

Refinement

R[F 2 > 2σ(F 2)] = 0.056

wR(F 2) = 0.163

S = 1.02

2991 reflections

155 parameters

H atoms treated by a mixture of independent and constrained refinement

Δρmax = 0.32 e Å−3

Δρmin = −0.18 e Å−3

Data collection: APEX2 (Bruker, 2004 ▶); cell refinement: APEX2 and SAINT-Plus (Bruker, 2004 ▶); data reduction: SAINT-Plus and XPREP (Bruker, 2004 ▶); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 (Farrugia, 1997 ▶); software used to prepare material for publication: SHELXL97.

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536811005058/bq2279sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536811005058/bq2279Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C28H37NO3	F(000) = 944
Mr = 435.59	Dx = 1.188 Mg m−3
Orthorhombic, Pnma	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ac 2n	Cell parameters from 4431 reflections
a = 7.7780 (5) Å	θ = 3.3–26.9°
b = 31.457 (2) Å	µ = 0.08 mm−1
c = 9.9560 (6) Å	T = 298 K
V = 2436.0 (3) Å3	Block, colorless
Z = 4	0.35 × 0.28 × 0.25 mm

Bruker APEXII CCD area-detector diffractometer	2991 independent reflections
Radiation source: fine-focus sealed tube	1900 reflections with I > 2σ(I)
graphite	Rint = 0.025
phi and ω scans	θmax = 28.3°, θmin = 2.2°
Absorption correction: multi-scan (SADABS; Bruker, 2004)	h = −10→9
Tmin = 0.974, Tmax = 0.981	k = −21→41
10360 measured reflections	l = −11→13

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.056	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.163	H atoms treated by a mixture of independent and constrained refinement
S = 1.02	w = 1/[σ2(Fo2) + (0.0606P)2 + 1.2024P] where P = (Fo2 + 2Fc2)/3
2991 reflections	(Δ/σ)max < 0.001
155 parameters	Δρmax = 0.32 e Å−3
0 restraints	Δρmin = −0.18 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
C1	1.1848 (3)	0.71161 (6)	0.10972 (19)	0.0455 (5)
H1	1.2239	0.7136	0.2031	0.055*
C2	1.3471 (3)	0.71050 (6)	0.0188 (2)	0.0487 (5)
H2	1.4165	0.6857	0.0432	0.058*
C3	1.4496 (4)	0.7500	0.0466 (3)	0.0494 (7)
C4	1.3130 (3)	0.70937 (6)	−0.1338 (2)	0.0523 (5)
H4A	1.4208	0.7044	−0.1801	0.063*
H4B	1.2372	0.6857	−0.1536	0.063*
C5	1.2325 (4)	0.7500	−0.1884 (3)	0.0547 (7)
H5A	1.1109	0.7500	−0.1667	0.066*
H5B	1.2429	0.7500	−0.2855	0.066*
C6	1.0781 (3)	0.67181 (6)	0.09708 (18)	0.0440 (4)
C7	0.9491 (3)	0.66660 (6)	0.0020 (2)	0.0542 (5)
H7	0.9213	0.6891	−0.0544	0.065*
C8	0.8618 (3)	0.62882 (7)	−0.0105 (2)	0.0560 (5)
H8	0.7765	0.6260	−0.0753	0.067*
C9	0.9001 (3)	0.59496 (6)	0.0730 (2)	0.0495 (5)
C10	1.0237 (3)	0.59983 (6)	0.1706 (2)	0.0530 (5)
H10	1.0487	0.5775	0.2288	0.064*
C11	1.1108 (3)	0.63806 (6)	0.1821 (2)	0.0500 (5)
H11	1.1936	0.6411	0.2489	0.060*
C12	0.8378 (3)	0.52285 (6)	0.1337 (2)	0.0601 (6)
H12A	0.8154	0.5296	0.2271	0.072*
H12B	0.9567	0.5139	0.1253	0.072*
C13	0.7190 (3)	0.48792 (7)	0.0868 (3)	0.0663 (6)
H13A	0.6013	0.4978	0.0945	0.080*
H13B	0.7413	0.4825	−0.0075	0.080*
C14	0.7355 (4)	0.44743 (7)	0.1615 (3)	0.0752 (7)
H14A	0.7082	0.4523	0.2553	0.090*
H14B	0.8538	0.4377	0.1566	0.090*
C15	0.6187 (4)	0.41318 (8)	0.1070 (3)	0.0882 (9)
H15A	0.5020	0.4231	0.1080	0.132*
H15B	0.6283	0.3882	0.1618	0.132*
H15C	0.6517	0.4065	0.0165	0.132*
N1	1.0856 (3)	0.7500	0.0803 (2)	0.0456 (5)
O1	1.5979 (3)	0.7500	0.0826 (2)	0.0692 (6)
O2	0.8061 (2)	0.55880 (5)	0.05158 (16)	0.0662 (5)
H1N	0.991 (4)	0.7500	0.127 (3)	0.052 (9)*

	U11	U22	U33	U12	U13	U23
C1	0.0549 (11)	0.0463 (10)	0.0354 (10)	0.0017 (9)	−0.0014 (8)	0.0015 (8)
C2	0.0523 (11)	0.0457 (10)	0.0480 (11)	0.0066 (9)	−0.0010 (9)	0.0022 (8)
C3	0.0480 (16)	0.0612 (17)	0.0392 (15)	0.000	−0.0013 (13)	0.000
C4	0.0609 (12)	0.0500 (11)	0.0459 (11)	−0.0011 (9)	0.0079 (10)	−0.0064 (9)
C5	0.0652 (19)	0.0616 (18)	0.0374 (15)	0.000	−0.0012 (14)	0.000
C6	0.0516 (10)	0.0444 (10)	0.0360 (10)	0.0038 (8)	0.0046 (8)	0.0018 (8)
C7	0.0670 (13)	0.0523 (12)	0.0434 (11)	0.0004 (10)	−0.0066 (10)	0.0120 (9)
C8	0.0617 (12)	0.0598 (13)	0.0465 (12)	−0.0056 (10)	−0.0106 (10)	0.0068 (9)
C9	0.0540 (11)	0.0458 (10)	0.0487 (12)	0.0017 (9)	0.0047 (9)	0.0021 (9)
C10	0.0566 (12)	0.0458 (11)	0.0565 (13)	0.0079 (9)	−0.0016 (10)	0.0125 (9)
C11	0.0534 (11)	0.0511 (11)	0.0456 (11)	0.0063 (9)	−0.0059 (9)	0.0055 (9)
C12	0.0604 (13)	0.0494 (12)	0.0704 (15)	0.0043 (10)	0.0027 (12)	0.0078 (10)
C13	0.0629 (13)	0.0600 (14)	0.0761 (17)	−0.0033 (11)	0.0005 (12)	0.0103 (12)
C14	0.0776 (16)	0.0589 (14)	0.0893 (19)	0.0063 (12)	0.0013 (15)	0.0050 (13)
C15	0.104 (2)	0.0565 (14)	0.104 (2)	−0.0075 (14)	0.0128 (18)	−0.0072 (14)
N1	0.0490 (13)	0.0441 (12)	0.0439 (13)	0.000	0.0054 (11)	0.000
O1	0.0563 (13)	0.0787 (15)	0.0725 (16)	0.000	−0.0153 (12)	0.000
O2	0.0762 (10)	0.0504 (8)	0.0721 (11)	−0.0099 (8)	−0.0117 (9)	0.0099 (7)

C1—N1	1.463 (2)	C9—O2	1.369 (2)
C1—C6	1.507 (3)	C9—C10	1.376 (3)
C1—C2	1.554 (3)	C10—C11	1.385 (3)
C1—H1	0.9800	C10—H10	0.9300
C2—C3	1.502 (2)	C11—H11	0.9300
C2—C4	1.543 (3)	C12—O2	1.417 (2)
C2—H2	0.9800	C12—C13	1.510 (3)
C3—O1	1.208 (3)	C12—H12A	0.9700
C3—C2i	1.502 (2)	C12—H12B	0.9700
C4—C5	1.523 (3)	C13—C14	1.481 (3)
C4—H4A	0.9700	C13—H13A	0.9700
C4—H4B	0.9700	C13—H13B	0.9700
C5—C4i	1.523 (3)	C14—C15	1.510 (4)
C5—H5A	0.9700	C14—H14A	0.9700
C5—H5B	0.9700	C14—H14B	0.9700
C6—C11	1.382 (3)	C15—H15A	0.9600
C6—C7	1.390 (3)	C15—H15B	0.9600
C7—C8	1.374 (3)	C15—H15C	0.9600
C7—H7	0.9300	N1—C1i	1.463 (2)
C8—C9	1.384 (3)	N1—H1N	0.87 (3)
C8—H8	0.9300
N1—C1—C6	112.25 (17)	O2—C9—C8	115.55 (18)
N1—C1—C2	109.31 (16)	C10—C9—C8	119.29 (19)
C6—C1—C2	112.33 (15)	C9—C10—C11	119.77 (18)
N1—C1—H1	107.6	C9—C10—H10	120.1
C6—C1—H1	107.6	C11—C10—H10	120.1
C2—C1—H1	107.6	C6—C11—C10	121.80 (19)
C3—C2—C4	106.96 (18)	C6—C11—H11	119.1
C3—C2—C1	107.76 (17)	C10—C11—H11	119.1
C4—C2—C1	115.76 (17)	O2—C12—C13	107.21 (19)
C3—C2—H2	108.7	O2—C12—H12A	110.3
C4—C2—H2	108.7	C13—C12—H12A	110.3
C1—C2—H2	108.7	O2—C12—H12B	110.3
O1—C3—C2	124.15 (12)	C13—C12—H12B	110.3
O1—C3—C2i	124.15 (12)	H12A—C12—H12B	108.5
C2—C3—C2i	111.7 (2)	C14—C13—C12	114.7 (2)
C5—C4—C2	113.74 (17)	C14—C13—H13A	108.6
C5—C4—H4A	108.8	C12—C13—H13A	108.6
C2—C4—H4A	108.8	C14—C13—H13B	108.6
C5—C4—H4B	108.8	C12—C13—H13B	108.6
C2—C4—H4B	108.8	H13A—C13—H13B	107.6
H4A—C4—H4B	107.7	C13—C14—C15	112.4 (2)
C4—C5—C4i	114.1 (2)	C13—C14—H14A	109.1
C4—C5—H5A	108.7	C15—C14—H14A	109.1
C4i—C5—H5A	108.7	C13—C14—H14B	109.1
C4—C5—H5B	108.7	C15—C14—H14B	109.1
C4i—C5—H5B	108.7	H14A—C14—H14B	107.9
H5A—C5—H5B	107.6	C14—C15—H15A	109.5
C11—C6—C7	117.37 (18)	C14—C15—H15B	109.5
C11—C6—C1	119.07 (18)	H15A—C15—H15B	109.5
C7—C6—C1	123.54 (17)	C14—C15—H15C	109.5
C8—C7—C6	121.36 (18)	H15A—C15—H15C	109.5
C8—C7—H7	119.3	H15B—C15—H15C	109.5
C6—C7—H7	119.3	C1—N1—C1i	111.3 (2)
C7—C8—C9	120.3 (2)	C1—N1—H1N	109.8 (9)
C7—C8—H8	119.8	C1i—N1—H1N	109.8 (9)
C9—C8—H8	119.8	C9—O2—C12	118.72 (17)
O2—C9—C10	125.15 (18)
N1—C1—C2—C3	58.7 (2)	C1—C6—C7—C8	176.3 (2)
C6—C1—C2—C3	−176.04 (17)	C6—C7—C8—C9	0.5 (3)
N1—C1—C2—C4	−61.0 (2)	C7—C8—C9—O2	−179.7 (2)
C6—C1—C2—C4	64.3 (2)	C7—C8—C9—C10	1.5 (3)
C4—C2—C3—O1	−111.7 (3)	O2—C9—C10—C11	179.82 (19)
C1—C2—C3—O1	123.2 (3)	C8—C9—C10—C11	−1.6 (3)
C4—C2—C3—C2i	66.0 (3)	C7—C6—C11—C10	2.4 (3)
C1—C2—C3—C2i	−59.1 (3)	C1—C6—C11—C10	−176.39 (18)
C3—C2—C4—C5	−52.9 (2)	C9—C10—C11—C6	−0.4 (3)
C1—C2—C4—C5	67.2 (2)	O2—C12—C13—C14	179.6 (2)
C2—C4—C5—C4i	43.6 (3)	C12—C13—C14—C15	−177.8 (2)
N1—C1—C6—C11	−145.94 (19)	C6—C1—N1—C1i	172.73 (12)
C2—C1—C6—C11	90.4 (2)	C2—C1—N1—C1i	−61.9 (2)
N1—C1—C6—C7	35.4 (3)	C10—C9—O2—C12	−1.0 (3)
C2—C1—C6—C7	−88.3 (2)	C8—C9—O2—C12	−179.72 (19)
C11—C6—C7—C8	−2.4 (3)	C13—C12—O2—C9	−179.18 (19)