Literature DB >> 21520840

Current status and future perspective of flattening filter free photon beams.

Dietmar Georg1, Tommy Knöös, Brendan McClean.   

Abstract

PURPOSE: Flattening filters (FFs) have been considered as an integral part of the treatment head of a medical accelerator for more than 50 years. The reasons for the longstanding use are, however, historical ones. Advanced treatment techniques, such as stereotactic radiotherapy or intensity modulated radiotherapy have stimulated the interest in operating linear accelerators in a flattening filter free (FFF) mode. The current manuscript reviews treatment head physics of FFF beams, describes their characteristics and the resulting potential advantages in their medical use, and closes with an outlook.
METHODS: A number of dosimetric benefits have been determined for FFF beams, which range from increased dose rate and dose per pulse to favorable output ratio in-air variation with field size, reduced energy variation across the beam, and reduced leakage and out-of-field dose, respectively. Finally, the softer photon spectrum of unflattened beams has implications on imaging strategies and radiation protection.
RESULTS: The dosimetric characteristics of FFF beams have an effect on treatment delivery, patient comfort, dose calculation accuracy, beam matching, absorbed dose determination, treatment planning, machine specific quality assurance, imaging, and radiation protection. When considering conventional C-arm linacs in a FFF mode, more studies are needed to specify and quantify the clinical advantages, especially with respect to treatment plan quality and quality assurance.
CONCLUSIONS: New treatment units are already on the market that operate without a FF or can be operated in a dedicated clinical FFF mode. Due to the convincing arguments of removing the FF, it is expected that more vendors will offer dedicated treatment units for advanced photon beam therapy in the near future. Several aspects related to standardization, dosimetry, treatment planning, and optimization need to be addressed in more detail in order to facilitate the clinical implementation of unflattened beams.

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Year:  2011        PMID: 21520840     DOI: 10.1118/1.3554643

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  93 in total

1.  Chest wall radiotherapy with volumetric modulated arcs and the potential role of flattening filter free photon beams.

Authors:  S Subramaniam; S Thirumalaiswamy; C Srinivas; G A Gandhi; M Kathirvel; K K Kumar; S Mallik; M Babaiah; Y Pawar; A Clivio; A Fogliata; P Mancosu; G Nicolini; E Vanetti; L Cozzi
Journal:  Strahlenther Onkol       Date:  2012-03-10       Impact factor: 3.621

2.  Polarity correction factor for flattening filter free photon beams in several cylindrical ionization chambers.

Authors:  Toshiyuki Ogata; Kazuyuki Uehara; Masao Nakayama; Shinji Tsudou; Takashi Masutani; Takanobu Okayama
Journal:  Radiol Phys Technol       Date:  2016-02-12

3.  Dose verification for respiratory-gated volumetric modulated arc therapy.

Authors:  Jianguo Qian; Lei Xing; Wu Liu; Gary Luxton
Journal:  Phys Med Biol       Date:  2011-07-13       Impact factor: 3.609

4.  Comparison of surface dose delivered by 7 MV-unflattened and 6 MV-flattened photon beams.

Authors:  Ashokkumar Sigamani; Arunai Nambiraj
Journal:  Rep Pract Oncol Radiother       Date:  2017-04-25

5.  Reirradiation of nasopharyngeal carcinoma focusing on volumetric modulated arcs with flattening filter-free beams.

Authors:  M Zhuang; L Huang; D Zhu; X Peng; Z Lin
Journal:  Br J Radiol       Date:  2015-06-02       Impact factor: 3.039

6.  Impact of flattening-filter-free radiation on the clonogenic survival of astrocytic cell lines.

Authors:  Caroline Steenken; Jens Fleckenstein; Stefan Kegel; Lennart Jahnke; Anna Simeonova; Linda Hartmann; Jens Kübler; Marlon R Veldwijk; Frederik Wenz; Carsten Herskind; Frank Anton Giordano
Journal:  Strahlenther Onkol       Date:  2015-03-13       Impact factor: 3.621

7.  Dosimetric influence of filtered and flattening filter free photon beam on rapid arc (RA) radiotherapy planning in case of cervix carcinoma.

Authors:  Lalit Kumar; Girigesh Yadav; Kothanda Raman Samuvel; Manindra Bhushan; Pawan Kumar; Mahammood Suhail; Manoj Pal
Journal:  Rep Pract Oncol Radiother       Date:  2016-10-17

8.  Analysis of physical parameters and determination of inflection point for Flattening Filter Free beams in medical linear accelerator.

Authors:  A Pichandi; Kadirampatti Mani Ganesh; Amalraj Jerin; Karunakaran Balaji; Gurunath Kilara
Journal:  Rep Pract Oncol Radiother       Date:  2014-07-15

9.  Node-positive left-sided breast cancer: does VMAT improve treatment plan quality with respect to IMRT?

Authors:  M Pasler; D Georg; S Bartelt; J Lutterbach
Journal:  Strahlenther Onkol       Date:  2013-03-24       Impact factor: 3.621

10.  Treatment of breast cancer with simultaneous integrated boost in hybrid plan technique : Influence of flattening filter-free beams.

Authors:  Marzieh Bahrainy; Matthias Kretschmer; Vincent Jöst; Astrid Kasch; Florian Würschmidt; Jörg Dahle; Jörn Lorenzen
Journal:  Strahlenther Onkol       Date:  2016-03-14       Impact factor: 3.621

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