Brian S Bodnar1, Marvin J Miller. 1. Chemspeed Technologies, Inc. 113 North Center Drive, North Brunswick, NJ 08906, USA.
Abstract
Organic transformations that result in the formation of multiple covalent bonds within the same reaction are some of the most powerful tools in synthetic organic chemistry. Nitrosocarbonyl hetero-Diels-Alder (HDA) reactions allow for the simultaneous stereospecific introduction of carbon-nitrogen and carbon-oxygen bonds in one synthetic step, and provide direct access to 3,6-dihydro-1,2-oxazines. This Review describes the development of the nitrosocarbonyl HDA reaction and the utility of the resulting oxazine ring in the synthesis of a variety of important, biologically active molecules.
Organic transformations that result in the formation of multiple covalent bonds within the same reaction are some of the most powerful tools in synthetic organic chemistry. Nitrosocarbonyl hetero-Diels-Alder (HDA) reactions allow for the simultaneous stereospecific introduction of n class="Chemical">carbon-nitrogen and carbon-oxygen bonds in one synthetic step, and provide direct access to 3,6-dihydro-1,2-oxazines. This Review describes the development of the nitrosocarbonyl HDA reaction and the utility of the resulting oxazine ring in the synthesis of a variety of important, biologically active molecules.
Authors: May Xiao-Wu Jiang; Bohan Jin; Jennifer L Gage; Alain Priour; Gordon Savela; Marvin J Miller Journal: J Org Chem Date: 2006-05-26 Impact factor: 4.354
Authors: Rohit Tiwari; Garrett C Moraski; Viktor Krchňák; Patricia A Miller; Mariangelli Colon-Martinez; Eliza Herrero; Allen G Oliver; Marvin J Miller Journal: J Am Chem Soc Date: 2013-02-25 Impact factor: 15.419