| Literature DB >> 23106266 |
Mahiuddin Baidya1, Kimberly A Griffin, Hisashi Yamamoto.
Abstract
The first example of a Cu-catalyzed asymmetric O-nitrosocarbonyl aldol reaction is described. This novel protocol allows convenient access to highly enantioenriched α-hydroxy-β-ketoesters including the antibacterial natural product kjellmanianone (up to 99% ee). MnO(2) was introduced as a mild efficient oxidant for the in situ generation of nitrosocarbonyl species from hydroxamic acid derivatives.Entities:
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Year: 2012 PMID： 23106266 PMCID： PMC3515642 DOI： 10.1021/ja309311z
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419