BACKGROUND: Intra-abdominal pressure (IAP) and intra-abdominal hypertension (IAH) are associated with significant morbidity and mortality in critically ill patients. Our aim was to assess the effects of IAH on liver function using the noninvasive liver function monitoring system LiMON and to assess the prognostic value of IAP in critically ill patients. METHODS: We conducted a retrospective analysis of critically ill patients who were treated in the intensive care unit (ICU). The IAP and indocyanine green plasma disappearance rate (ICG-PDR) measurements were made within 24 hours after admission to the ICU and repeated 12 hours later. Intra-abdominal pressure was measured via a Foley bladder catheter, and ICG elimination tests were conducted concurrently using the LiMON. RESULTS: We included 30 critically ill patients (17 women and 13 men aged 28-89 yr) in our analysis. Statistical analysis showed that the baseline IAP values were significantly higher among nonsurvivors than survivors (19.38 [standard deviation; SD 2.08] v. 13.07 [SD 0.99]). The twelfth-hour IAP values were higher than baseline measurements among nonsurvivors (21.50 [SD 1.96]) and lower than baseline measurements among survivors (11.71 [SD 1.54]); the difference between groups was significant (p < 0.001). The baseline ICG-PDR values were significantly lower among nonsurvivors than survivors (10.86 [SD 3.35] v. 24.51 [SD 6.78]), and the twelfth-hour ICGPDR values were decreased in all groups; the difference between groups was significant (p < 0.001). CONCLUSION: Our results suggest that measurement of ICG-PDR with the LiMON is a good predictor of the effects of IAP on liver function and, thus, can be recommended for the evaluation of critically ill patients.
BACKGROUND: Intra-abdominal pressure (IAP) and intra-abdominal hypertension (IAH) are associated with significant morbidity and mortality in critically illpatients. Our aim was to assess the effects of IAH on liver function using the noninvasive liver function monitoring system LiMON and to assess the prognostic value of IAP in critically illpatients. METHODS: We conducted a retrospective analysis of critically illpatients who were treated in the intensive care unit (ICU). The IAP and indocyanine green plasma disappearance rate (ICG-PDR) measurements were made within 24 hours after admission to the ICU and repeated 12 hours later. Intra-abdominal pressure was measured via a Foley bladder catheter, and ICG elimination tests were conducted concurrently using the LiMON. RESULTS: We included 30 critically illpatients (17 women and 13 men aged 28-89 yr) in our analysis. Statistical analysis showed that the baseline IAP values were significantly higher among nonsurvivors than survivors (19.38 [standard deviation; SD 2.08] v. 13.07 [SD 0.99]). The twelfth-hour IAP values were higher than baseline measurements among nonsurvivors (21.50 [SD 1.96]) and lower than baseline measurements among survivors (11.71 [SD 1.54]); the difference between groups was significant (p < 0.001). The baseline ICG-PDR values were significantly lower among nonsurvivors than survivors (10.86 [SD 3.35] v. 24.51 [SD 6.78]), and the twelfth-hour ICGPDR values were decreased in all groups; the difference between groups was significant (p < 0.001). CONCLUSION: Our results suggest that measurement of ICG-PDR with the LiMON is a good predictor of the effects of IAP on liver function and, thus, can be recommended for the evaluation of critically illpatients.
Authors: Manu L N G Malbrain; Davide Chiumello; Paolo Pelosi; David Bihari; Richard Innes; V Marco Ranieri; Monica Del Turco; Alexander Wilmer; Nicola Brienza; Vincenzo Malcangi; Jonathan Cohen; Andre Japiassu; Bart L De Keulenaer; Ronny Daelemans; Luc Jacquet; Pierre-François Laterre; Günther Frank; Paulo de Souza; Bruno Cesana; Luciano Gattinoni Journal: Crit Care Med Date: 2005-02 Impact factor: 7.598
Authors: Pierre Michelet; Antoine Roch; Marc Gainnier; Jean-Marie Sainty; Jean-Pierre Auffray; Laurent Papazian Journal: Crit Care Date: 2005-03-31 Impact factor: 9.097
Authors: Ester Párraga Ros; Laura Correa-Martín; Francisco M Sánchez-Margallo; Irma Eugenia Candanosa-Aranda; Manu L N G Malbrain; Robert Wise; Rafael Latorre; Octavio López Albors; Gregorio Castellanos Journal: Surg Endosc Date: 2018-05-17 Impact factor: 4.584
Authors: Ester Párraga Ros; Laura Correa-Martín; Francisco M Sánchez-Margallo; Irma Eugenia Candanosa-Aranda; Manu L N G Malbrain; Robert Wise; Rafael Latorre; Octavio López Albors; Gregorio Castellanos Journal: PLoS One Date: 2018-01-22 Impact factor: 3.240
Authors: Ulrich Mayr; Leonie Fahrenkrog-Petersen; Gonzalo Batres-Baires; Alexander Herner; Sebastian Rasch; Roland M Schmid; Wolfgang Huber; Tobias Lahmer Journal: Ann Intensive Care Date: 2018-07-06 Impact factor: 6.925
Authors: Glenn Hernandez; Tomas Regueira; Alejandro Bruhn; Ricardo Castro; Maximiliano Rovegno; Andrea Fuentealba; Enrique Veas; Dolores Berrutti; Jorge Florez; Eduardo Kattan; Celeste Martin; Can Ince Journal: Ann Intensive Care Date: 2012-10-15 Impact factor: 6.925
Authors: Manu Lng Malbrain; Dries Viaene; Andreas Kortgen; Inneke De Laet; Hilde Dits; Niels Van Regenmortel; Karen Schoonheydt; Michael Bauer Journal: Ann Intensive Care Date: 2012-12-20 Impact factor: 6.925