| Literature DB >> 21404360 |
Abstract
NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide site-resolved information about the conformation entropy of binding, as well as about energetically excited conformational states. Recent advances have enabled the application of NMR for the characterization of supramolecular systems. A summary of mechanisms underpinning protein activity regulation revealed by the application of NMR spectroscopy in a number of biological systems studied in the lab is provided.Mesh:
Substances:
Year: 2011 PMID: 21404360 PMCID: PMC3125862 DOI: 10.1002/pro.614
Source DB: PubMed Journal: Protein Sci ISSN: 0961-8368 Impact factor: 6.725