Literature DB >> 21398531

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

Dina H Horna1, Cristina Gómez, Carlos Olano, Martina Palomino-Schätzlein, Antonio Pineda-Lucena, Rodrigo J Carbajo, Alfredo F Braña, Carmen Méndez, José A Salas.   

Abstract

The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production.

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Year:  2011        PMID： 21398531      PMCID： PMC3133142          DOI： 10.1128/JB.00108-11

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

Review 1.  Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Nat Prod Rep       Date:  2010-04       Impact factor: 13.423

2.  Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis.

Authors:  Marina Sánchez-Hidalgo; Luz Elena Núñez; Carmen Méndez; José A Salas
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

3.  Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.

Authors:  Nuria Menéndez; Mohammad Nur-e-Alam; Carsten Fischer; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Journal:  Appl Environ Microbiol       Date:  2006-01       Impact factor: 4.792

4.  Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.

Authors:  C Bihlmaier; E Welle; C Hofmann; K Welzel; A Vente; E Breitling; M Müller; S Glaser; A Bechthold
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

Review 5.  Tetramic and tetronic acids: an update on new derivatives and biological aspects.

Authors:  Rainer Schobert; Andrea Schlenk
Journal:  Bioorg Med Chem       Date:  2008-02-26       Impact factor: 3.641

Review 6.  Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Nat Prod Rep       Date:  2009-02-27       Impact factor: 13.423

7.  Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.

Authors:  Carlos Olano; Cristina Gómez; María Pérez; Martina Palomino; Antonio Pineda-Lucena; Rodrigo J Carbajo; Alfredo F Braña; Carmen Méndez; José A Salas
Journal:  Chem Biol       Date:  2009-10-30

8.  Investigations of valanimycin biosynthesis: elucidation of the role of seryl-tRNA.

Authors:  Ram P Garg; Xuelei L Qian; Lawrence B Alemany; Sean Moran; Ronald J Parry
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-01       Impact factor: 11.205

9.  Microbial N-demethylation: biotransformation and recovery of a drug metabolite.

Authors:  Brian L Davis; Mark S Liu; Ronald L Hanson; William L Parker; Ramesh N Patel
Journal:  Biotechnol Appl Biochem       Date:  2009-06       Impact factor: 2.431

10.  Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Authors:  Muriel Gondry; Ludovic Sauguet; Pascal Belin; Robert Thai; Rachel Amouroux; Carine Tellier; Karine Tuphile; Mickaël Jacquet; Sandrine Braud; Marie Courçon; Cédric Masson; Steven Dubois; Sylvie Lautru; Alain Lecoq; Shin-ichi Hashimoto; Roger Genet; Jean-Luc Pernodet
Journal:  Nat Chem Biol       Date:  2009-06       Impact factor: 15.040
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  15 in total

1.  Insights into the roles of exogenous glutamate and proline in improving streptolydigin production of Streptomyces lydicus with metabolomic analysis.

Authors:  Jing-Sheng Cheng; Shao-Fei Cui; Ming-Zhu Ding; Ying-Jin Yuan
Journal:  J Ind Microbiol Biotechnol       Date:  2013-08-29       Impact factor: 3.346

2.  Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.

Authors:  Cristina Gómez; Dina H Horna; Carlos Olano; Martina Palomino-Schätzlein; Antonio Pineda-Lucena; Rodrigo J Carbajo; Alfredo F Braña; Carmen Méndez; José A Salas
Journal:  J Bacteriol       Date:  2011-06-10       Impact factor: 3.490

3.  Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics.

Authors:  Sergey V Pronin; Anthony Martinez; Konstantin Kuznedelov; Konstantin Severinov; Howard A Shuman; Sergey A Kozmin
Journal:  J Am Chem Soc       Date:  2011-07-20       Impact factor: 15.419

Review 4.  The many roles of glutamate in metabolism.

Authors:  Mark C Walker; Wilfred A van der Donk
Journal:  J Ind Microbiol Biotechnol       Date:  2015-09-01       Impact factor: 3.346

5.  Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes.

Authors:  Dominik A Herbst; Björn Boll; Georg Zocher; Thilo Stehle; Lutz Heide
Journal:  J Biol Chem       Date:  2012-11-28       Impact factor: 5.157

6.  Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.

Authors:  Cristina Gómez; Dina H Horna; Carlos Olano; Carmen Méndez; José A Salas
Journal:  Microb Biotechnol       Date:  2012-06-22       Impact factor: 5.813

7.  Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative.

Authors:  Raúl García Salcedo; Carlos Olano; Cristina Gómez; Rogelio Fernández; Alfredo F Braña; Carmen Méndez; Fernando de la Calle; José A Salas
Journal:  Microb Cell Fact       Date:  2016-02-22       Impact factor: 5.328

8.  Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.

Authors:  Raúl García Salcedo; Carlos Olano; Rogelio Fernández; Alfredo F Braña; Carmen Méndez; Fernando de la Calle; José A Salas
Journal:  Microb Cell Fact       Date:  2016-11-09       Impact factor: 5.328

9.  Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.

Authors:  Carlos Olano; Ignacio García; Aranzazu González; Miriam Rodriguez; Daniel Rozas; Julio Rubio; Marina Sánchez-Hidalgo; Alfredo F Braña; Carmen Méndez; José A Salas
Journal:  Microb Biotechnol       Date:  2014-03-04       Impact factor: 5.813

10.  New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis.

Authors:  Aránzazu González; Miriam Rodríguez; Alfredo F Braña; Carmen Méndez; José A Salas; Carlos Olano
Journal:  Microb Cell Fact       Date:  2016-03-21       Impact factor: 5.328
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