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Literature DB >> 19387499

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.

Carlos Olano¹, Carmen Méndez, José A Salas.

Abstract

Covering: up to October 2008. Antitumor compounds produced by actinomycetes and novel derivatives generated by combinatorial biosynthesis are reviewed (with 318 references cited.) The different structural groups for which the relevant gene clusters have been isolated and characterized are reviewed, with a description of the strategies used for the generation of the novel derivatives and the activities of these compounds against tumor cell lines.

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 19387499 DOI： 10.1039/b822528a

Source DB: PubMed Journal: Nat Prod Rep ISSN： 0265-0568 Impact factor: 13.423

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Cited

34 in total

Review 1. Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.

Authors: Beile Gao; Radhey S Gupta
Journal: Microbiol Mol Biol Rev Date: 2012-03 Impact factor: 11.056

2. Statistical optimization and anticancer activity of a red pigment isolated from Streptomyces sp. PM4.

Authors: Valliappan Karuppiah; Chandramohan Aarthi; Kannan Sivakumar; Lakshmanan Kannan
Journal: Asian Pac J Trop Biomed Date: 2013-08

Review 3. Genomic basis for natural product biosynthetic diversity in the actinomycetes.

Authors: Markus Nett; Haruo Ikeda; Bradley S Moore
Journal: Nat Prod Rep Date: 2009-09-01 Impact factor: 13.423

4. Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.

Authors: Ah Reum Han; Je Won Park; Mi Kyeong Lee; Yeon Hee Ban; Young Ji Yoo; Eun Ji Kim; Eunji Kim; Byung-Gee Kim; Jae Kyung Sohng; Yeo Joon Yoon
Journal: Appl Environ Microbiol Date: 2011-05-20 Impact factor: 4.792

Review 5. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.

Authors: Xue Gao; Peng Wang; Yi Tang
Journal: Appl Microbiol Biotechnol Date: 2010-09-19 Impact factor: 4.813

6. Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

Authors: Dina H Horna; Cristina Gómez; Carlos Olano; Martina Palomino-Schätzlein; Antonio Pineda-Lucena; Rodrigo J Carbajo; Alfredo F Braña; Carmen Méndez; José A Salas
Journal: J Bacteriol Date: 2011-03-11 Impact factor: 3.490

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.

Review 1. Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.

2. Statistical optimization and anticancer activity of a red pigment isolated from Streptomyces sp. PM4.

Review 3. Genomic basis for natural product biosynthetic diversity in the actinomycetes.

4. Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.

Review 5. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.

6. Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

Review 7. Antitumor compounds from marine actinomycetes.

8. Characterization of cytotoxic compound from marine sediment derived actinomycete Streptomyces avidinii strain SU4.

9. An "olivomycin A" derivative from a sponge-associated Streptomyces sp. strain SP 85.

10. Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica.