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Literature DB >> 21387490

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.

Liangcai Gu¹, Eli B Eisman, Somnath Dutta, Titus M Franzmann, Stefan Walter, William H Gerwick, Georgios Skiniotis, David H Sherman.

Abstract

Entities: Chemical Disease Species

Mesh：

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Year: 2011 PMID： 21387490 PMCID： PMC3081611 DOI： 10.1002/anie.201005280

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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20 in total

1. Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.

Authors: Dheeraj Khare; Bo Wang; Liangcai Gu; Jamie Razelun; David H Sherman; William H Gerwick; Kristina Håkansson; Janet L Smith
Journal: Proc Natl Acad Sci U S A Date: 2010-07-26 Impact factor: 11.205

Review 2. Structure and mechanism of the 6-deoxyerythronolide B synthase.

Authors: Chaitan Khosla; Yinyan Tang; Alice Y Chen; Nathan A Schnarr; David E Cane
Journal: Annu Rev Biochem Date: 2007 Impact factor: 23.643

3. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.

Authors: L E Quadri; P H Weinreb; M Lei; M M Nakano; P Zuber; C T Walsh
Journal: Biochemistry Date: 1998-02-10 Impact factor: 3.162

4. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles.

Authors: Jörn Piel
Journal: Proc Natl Acad Sci U S A Date: 2002-10-14 Impact factor: 11.205

5. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

Authors: P Verdier-Pinard; J Y Lai; H D Yoo; J Yu; B Marquez; D G Nagle; M Nambu; J D White; J R Falck; W H Gerwick; B W Day; E Hamel
Journal: Mol Pharmacol Date: 1998-01 Impact factor: 4.436

6. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.

Authors: Zunxue Chang; Namthip Sitachitta; James V Rossi; Mary Ann Roberts; Patricia M Flatt; Junyong Jia; David H Sherman; William H Gerwick
Journal: J Nat Prod Date: 2004-08 Impact factor: 4.050

7. Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

Authors: A Kassem El-Sayed; Joanne Hothersall; Sian M Cooper; Elton Stephens; Thomas J Simpson; Christopher M Thomas
Journal: Chem Biol Date: 2003-05

8. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.

Authors: Todd W Geders; Liangcai Gu; Jonathan C Mowers; Haichuan Liu; William H Gerwick; Kristina Håkansson; David H Sherman; Janet L Smith
Journal: J Biol Chem Date: 2007-10-10 Impact factor: 5.157

9. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.

Authors: Daniel J Edwards; Brian L Marquez; Lisa M Nogle; Kerry McPhail; Douglas E Goeger; Mary Ann Roberts; William H Gerwick
Journal: Chem Biol Date: 2004-06

Review 10. The chemical versatility of natural-product assembly lines.

Authors: Christopher T Walsh
Journal: Acc Chem Res Date: 2007-05-17 Impact factor: 22.384

17 in total

Review 1. The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

Authors: Adrian T Keatinge-Clay
Journal: Chem Rev Date: 2017-04-10 Impact factor: 60.622

2. Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant.

Authors: Mengbin Chen; Qikun Liu; Shu-Shan Gao; Abbegayle E Young; Steven E Jacobsen; Yi Tang
Journal: Proc Natl Acad Sci U S A Date: 2019-03-06 Impact factor: 11.205

3. Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase.

Authors: Alena Busche; Daniel Gottstein; Christopher Hein; Nina Ripin; Irina Pader; Peter Tufar; Eli B Eisman; Liangcai Gu; Christopher T Walsh; David H Sherman; Frank Löhr; Peter Güntert; Volker Dötsch
Journal: ACS Chem Biol Date: 2011-12-15 Impact factor: 5.100

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.

1. Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.

Review 2. Structure and mechanism of the 6-deoxyerythronolide B synthase.

3. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.

4. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles.

5. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

6. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.

7. Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

8. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.

9. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.

Review 10. The chemical versatility of natural-product assembly lines.

Review 1. The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

2. Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant.

3. Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase.

Review 4. Insights from the sea: structural biology of marine polyketide synthases.

5. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.

6. Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

Review 7. Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery.

8. Production of proteasome inhibitor syringolin A by the endophyte Rhizobium sp. strain AP16.

Review 9. Protein-protein interactions in "cis-AT" polyketide synthases.

Review 10. A comprehensive catalogue of polyketide synthase gene clusters in lichenizing fungi.