OBJECTIVES: Our aim was to determine whether ablated liver parenchyma surrounding a tumour can be assessed by MRI with ferucarbotran administered prior to radiofrequency ablation (RFA) compared with enhanced CT. METHODS: 55 hepatocellular carcinomas (HCCs) in 42 patients and 5 metastatic liver cancers in 3 patients were treated by RFA after ferucarbotran administration. We then performed T(2)* weighted MRI after 1 week and enhanced CT after 1 month. T(2)* weighted MRI demonstrated the ablated parenchyma as a low-intensity rim around the high intensity of the ablated tumour in these cases. The assessment was allocated to one of three grades: margin (+), high-intensity area with continuous low-intensity rim; margin zero, high-intensity area with discontinuous low-intensity rim; and margin (-), high-intensity area extending beyond the low-intensity rim. RESULTS: Margin (+), margin zero and margin (-) were found in 17, 35 and 5 nodules, respectively. All 17 nodules with margin (+) and 13 of those with margin zero were assessed as having sufficient ablative margins on CT. The remaining 22 nodules with margin zero had insufficient margins on CT. The overall agreement between MRI and CT for the diagnosis of the ablative margin was moderate (κ = 0.507, p < 0.001). No local recurrence was found in 15 HCC nodules with margin (+), whereas local recurrence was found in 4 (11.8%) out of 34 HCC nodules with margin zero. CONCLUSION: Administration of ferucarbotran before RFA enables the ablative margin to be visualised as a low-intensity rim, and also enables the evaluation of the ablative margin to be made earlier and more easily than with enhanced CT.
OBJECTIVES: Our aim was to determine whether ablated liver parenchyma surrounding a tumour can be assessed by MRI with ferucarbotran administered prior to radiofrequency ablation (RFA) compared with enhanced CT. METHODS: 55 hepatocellular carcinomas (HCCs) in 42 patients and 5 metastatic liver cancers in 3 patients were treated by RFA after ferucarbotran administration. We then performed T(2)* weighted MRI after 1 week and enhanced CT after 1 month. T(2)* weighted MRI demonstrated the ablated parenchyma as a low-intensity rim around the high intensity of the ablated tumour in these cases. The assessment was allocated to one of three grades: margin (+), high-intensity area with continuous low-intensity rim; margin zero, high-intensity area with discontinuous low-intensity rim; and margin (-), high-intensity area extending beyond the low-intensity rim. RESULTS: Margin (+), margin zero and margin (-) were found in 17, 35 and 5 nodules, respectively. All 17 nodules with margin (+) and 13 of those with margin zero were assessed as having sufficient ablative margins on CT. The remaining 22 nodules with margin zero had insufficient margins on CT. The overall agreement between MRI and CT for the diagnosis of the ablative margin was moderate (κ = 0.507, p < 0.001). No local recurrence was found in 15 HCC nodules with margin (+), whereas local recurrence was found in 4 (11.8%) out of 34 HCC nodules with margin zero. CONCLUSION: Administration of ferucarbotran before RFA enables the ablative margin to be visualised as a low-intensity rim, and also enables the evaluation of the ablative margin to be made earlier and more easily than with enhanced CT.
Authors: Y Imai; T Murakami; S Yoshida; M Nishikawa; M Ohsawa; K Tokunaga; M Murata; K Shibata; S Zushi; M Kurokawa; T Yonezawa; S Kawata; M Takamura; H Nagano; M Sakon; M Monden; K Wakasa; H Nakamura Journal: Hepatology Date: 2000-08 Impact factor: 17.425
Authors: Kai Liu; Xu He; Xue-Zhong Lei; Lian-San Zhao; Hong Tang; Li Liu; Bing-Jun Lei Journal: World J Gastroenterol Date: 2003-09 Impact factor: 5.742
Authors: B Hamm; T Staks; M Taupitz; R Maibauer; A Speidel; A Huppertz; T Frenzel; R Lawaczeck; K J Wolf; L Lange Journal: J Magn Reson Imaging Date: 1994 Sep-Oct Impact factor: 4.813
Authors: D D Stark; R Weissleder; G Elizondo; P F Hahn; S Saini; L E Todd; J Wittenberg; J T Ferrucci Journal: Radiology Date: 1988-08 Impact factor: 11.105
Authors: Prashant Chandrasekharan; Zhi Wei Tay; Xinyi Yedda Zhou; Elaine Yu; Ryan Orendorff; Daniel Hensley; Quincy Huynh; K L Barry Fung; Caylin Colson VanHook; Patrick Goodwill; Bo Zheng; Steven Conolly Journal: Br J Radiol Date: 2018-06-21 Impact factor: 3.039