Literature DB >> 21384820

A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.

Kangjian Qiao1, Hui Zhou, Wei Xu, Wenjun Zhang, Neil Garg, Yi Tang.   

Abstract

A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free thiols was explored to produce >60 different thiopyrazine compounds.

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Year:  2011        PMID： 21384820      PMCID： PMC3064727          DOI： 10.1021/ol200288w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  26 in total

1.  The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.

Authors:  Thomas A Keating; C Gary Marshall; Christopher T Walsh; Amy E Keating
Journal:  Nat Struct Biol       Date:  2002-07

2.  The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase.

Authors:  Shubha Maiya; Alexander Grundmann; Shu-Ming Li; Geoffrey Turner
Journal:  Chembiochem       Date:  2006-07       Impact factor: 3.164

Review 3.  Biosynthesis of nonribosomal peptides1.

Authors:  Robert Finking; Mohamed A Marahiel
Journal:  Annu Rev Microbiol       Date:  2004       Impact factor: 15.500

4.  Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity.

Authors:  Wendy L Kelly; Nathan J Hillson; Christopher T Walsh
Journal:  Biochemistry       Date:  2005-10-11       Impact factor: 3.162

5.  Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

Authors:  B A Pfeifer; S J Admiraal; H Gramajo; D E Cane; C Khosla
Journal:  Science       Date:  2001-03-02       Impact factor: 47.728

6.  Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.

Authors:  Xue Gao; Yit-Heng Chooi; Brian D Ames; Peng Wang; Christopher T Walsh; Yi Tang
Journal:  J Am Chem Soc       Date:  2011-02-07       Impact factor: 15.419

7.  Mutational analysis of the C-domain in nonribosomal peptide synthesis.

Authors:  Veit Bergendahl; Uwe Linne; Mohamed A Marahiel
Journal:  Eur J Biochem       Date:  2002-01

Review 8.  Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.

Authors:  Jonathan A Tobert
Journal:  Nat Rev Drug Discov       Date:  2003-07       Impact factor: 84.694

9.  Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis.

Authors:  Thomas Duerfahrt; Katrin Eppelmann; Rolf Müller; Mohamed A Marahiel
Journal:  Chem Biol       Date:  2004-02

10.  Biosynthesis of cyclosporin A: partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum.

Authors:  R Zocher; T Nihira; E Paul; N Madry; H Peeters; H Kleinkauf; U Keller
Journal:  Biochemistry       Date:  1986-02-11       Impact factor: 3.162
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  11 in total

Review 1.  Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.

Authors:  Heather L Condurso; Steven D Bruner
Journal:  Nat Prod Rep       Date:  2012-06-25       Impact factor: 13.423

2.  Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.

Authors:  David J Gonzalez; Yuquan Xu; Yu-Liang Yang; Eduardo Esquenazi; Wei-Ting Liu; Anna Edlund; Tram Duong; Liangcheng Du; István Molnár; William H Gerwick; Paul R Jensen; Michael Fischbach; Chih-Chuang Liaw; Paul Straight; Victor Nizet; Pieter C Dorrestein
Journal:  J Proteomics       Date:  2012-05-26       Impact factor: 4.044

3.  Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1.

Authors:  Kangjian Qiao; Yit-Heng Chooi; Yi Tang
Journal:  Metab Eng       Date:  2011-10-01       Impact factor: 9.783

4.  Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

Authors:  Meng Wang; Mirko Beissner; Huimin Zhao
Journal:  Chem Biol       Date:  2014-01-09

5.  Navigating the fungal polyketide chemical space: from genes to molecules.

Authors:  Yit-Heng Chooi; Yi Tang
Journal:  J Org Chem       Date:  2012-09-13       Impact factor: 4.354

Review 6.  Advances in Aspergillus secondary metabolite research in the post-genomic era.

Authors:  James F Sanchez; Amber D Somoza; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Rep       Date:  2012-01-06       Impact factor: 13.423

7.  Amino acid variability in the peptide composition of a suite of amphiphilic peptide siderophores from an open ocean Vibrio species.

Authors:  Julia M Gauglitz; Alison Butler
Journal:  J Biol Inorg Chem       Date:  2013-04-06       Impact factor: 3.358

Review 8.  Lessons learned from the transformation of natural product discovery to a genome-driven endeavor.

Authors:  Caitlin D Deane; Douglas A Mitchell
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-19       Impact factor: 3.346

9.  Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

Authors:  Daniel J Wilson; Ce Shi; Aaron M Teitelbaum; Andrew M Gulick; Courtney C Aldrich
Journal:  Biochemistry       Date:  2013-01-23       Impact factor: 3.162

10.  A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum.

Authors:  Yit-Heng Chooi; Mariano Jordi Muria-Gonzalez; Peter S Solomon
Journal:  Mycology       Date:  2014-06-24
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