Literature DB >> 21384820

A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.

Kangjian Qiao1, Hui Zhou, Wei Xu, Wenjun Zhang, Neil Garg, Yi Tang.   

Abstract

A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize n class="Chemical">thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free thiols was explored to produce >60 different thiopyrazine compounds.

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Year:  2011        PMID： 21384820      PMCID： PMC3064727          DOI： 10.1021/ol200288w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  26 in total

1.  The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.

Authors:  Thomas A Keating; C Gary Marshall; Christopher T Walsh; Amy E Keating
Journal:  Nat Struct Biol       Date:  2002-07

2.  The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase.

Authors:  Shubha Maiya; Alexander Grundmann; Shu-Ming Li; Geoffrey Turner
Journal:  Chembiochem       Date:  2006-07       Impact factor: 3.164

Review 3.  Biosynthesis of nonribosomal peptides1.

Authors:  Robert Finking; Mohamed A Marahiel
Journal:  Annu Rev Microbiol       Date:  2004       Impact factor: 15.500

4.  Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity.

Authors:  Wendy L Kelly; Nathan J Hillson; Christopher T Walsh
Journal:  Biochemistry       Date:  2005-10-11       Impact factor: 3.162

5.  Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

Authors:  B A Pfeifer; S J Admiraal; H Gramajo; D E Cane; C Khosla
Journal:  Science       Date:  2001-03-02       Impact factor: 47.728

6.  Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.

Authors:  Xue Gao; Yit-Heng Chooi; Brian D Ames; Peng Wang; Christopher T Walsh; Yi Tang
Journal:  J Am Chem Soc       Date:  2011-02-07       Impact factor: 15.419

7.  Mutational analysis of the C-domain in nonribosomal peptide synthesis.

Authors:  Veit Bergendahl; Uwe Linne; Mohamed A Marahiel
Journal:  Eur J Biochem       Date:  2002-01

Review 8.  Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.

Authors:  Jonathan A Tobert
Journal:  Nat Rev Drug Discov       Date:  2003-07       Impact factor: 84.694

9.  Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis.

Authors:  Thomas Duerfahrt; Katrin Eppelmann; Rolf Müller; Mohamed A Marahiel
Journal:  Chem Biol       Date:  2004-02

10.  Biosynthesis of cyclosporin A: partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum.

Authors:  R Zocher; T Nihira; E Paul; N Madry; H Peeters; H Kleinkauf; U Keller
Journal:  Biochemistry       Date:  1986-02-11       Impact factor: 3.162
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  11 in total

Review 1.  Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.

Authors:  Heather L Condurso; Steven D Bruner
Journal:  Nat Prod Rep       Date:  2012-06-25       Impact factor: 13.423

2.  Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.

Authors:  David J Gonzalez; Yuquan Xu; Yu-Liang Yang; Eduardo Esquenazi; Wei-Ting Liu; Anna Edlund; Tram Duong; Liangcheng Du; István Molnár; William H Gerwick; Paul R Jensen; Michael Fischbach; Chih-Chuang Liaw; Paul Straight; Victor Nizet; Pieter C Dorrestein
Journal:  J Proteomics       Date:  2012-05-26       Impact factor: 4.044

3.  Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1.

Authors:  Kangjian Qiao; Yit-Heng Chooi; Yi Tang
Journal:  Metab Eng       Date:  2011-10-01       Impact factor: 9.783

4.  Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

Authors:  Meng Wang; Mirko Beissner; Huimin Zhao
Journal:  Chem Biol       Date:  2014-01-09

5.  Navigating the fungal polyketide chemical space: from genes to molecules.

Authors:  Yit-Heng Chooi; Yi Tang
Journal:  J Org Chem       Date:  2012-09-13       Impact factor: 4.354

Review 6.  Advances in Aspergillus secondary metabolite research in the post-genomic era.

Authors:  James F Sanchez; Amber D Somoza; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Rep       Date:  2012-01-06       Impact factor: 13.423

7.  Amino acid variability in the peptide composition of a suite of amphiphilic peptide siderophores from an open ocean Vibrio species.

Authors:  Julia M Gauglitz; Alison Butler
Journal:  J Biol Inorg Chem       Date:  2013-04-06       Impact factor: 3.358

Review 8.  Lessons learned from the transformation of natural product discovery to a genome-driven endeavor.

Authors:  Caitlin D Deane; Douglas A Mitchell
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-19       Impact factor: 3.346

9.  Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

Authors:  Daniel J Wilson; Ce Shi; Aaron M Teitelbaum; Andrew M Gulick; Courtney C Aldrich
Journal:  Biochemistry       Date:  2013-01-23       Impact factor: 3.162

10.  A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum.

Authors:  Yit-Heng Chooi; Mariano Jordi Muria-Gonzalez; Peter S Solomon
Journal:  Mycology       Date:  2014-06-24
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