Literature DB >> 22228366

Advances in Aspergillus secondary metabolite research in the post-genomic era.

James F Sanchez1, Amber D Somoza, Nancy P Keller, Clay C C Wang.   

Abstract

This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.

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Year:  2012        PMID： 22228366      PMCID： PMC4568942          DOI： 10.1039/c2np00084a

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  142 in total

1.  Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

Authors:  Robert A Cramer; Michael P Gamcsik; Rhea M Brooking; Laura K Najvar; William R Kirkpatrick; Thomas F Patterson; Carl J Balibar; John R Graybill; John R Perfect; Soman N Abraham; William J Steinbach
Journal:  Eukaryot Cell       Date:  2006-06

2.  The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron.

Authors:  Kathrin Reiber; Emer P Reeves; Claire M Neville; Robert Winkler; Peter Gebhardt; Kevin Kavanagh; Sean Doyle
Journal:  FEMS Microbiol Lett       Date:  2005-07-01       Impact factor: 2.742

3.  Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.

Authors:  Sebastian Bergmann; Julia Schümann; Kirstin Scherlach; Corinna Lange; Axel A Brakhage; Christian Hertweck
Journal:  Nat Chem Biol       Date:  2007-03-18       Impact factor: 15.040

4.  Genomic mining for Aspergillus natural products.

Authors:  Jin Woo Bok; Dirk Hoffmeister; Lori A Maggio-Hall; Renato Murillo; Jeremy D Glasner; Nancy P Keller
Journal:  Chem Biol       Date:  2006-01

5.  Six new genes required for production of T-toxin, a polyketide determinant of high virulence of Cochliobolus heterostrophus to maize.

Authors:  Patrik Inderbitzin; Thipa Asvarak; B Gillian Turgeon
Journal:  Mol Plant Microbe Interact       Date:  2010-04       Impact factor: 4.171

6.  Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA.

Authors:  Sarah Bouhired; Monika Weber; Anita Kempf-Sontag; Nancy P Keller; Dirk Hoffmeister
Journal:  Fungal Genet Biol       Date:  2007-01-08       Impact factor: 3.495

7.  Aspergillus nidulans mutants defective in stc gene cluster regulation.

Authors:  R A Butchko; T H Adams; N P Keller
Journal:  Genetics       Date:  1999-10       Impact factor: 4.562

Review 8.  Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis.

Authors:  Taylor R T Dagenais; Nancy P Keller
Journal:  Clin Microbiol Rev       Date:  2009-07       Impact factor: 26.132

9.  The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones.

Authors:  Patrick Schneider; Monika Weber; Dirk Hoffmeister
Journal:  Fungal Genet Biol       Date:  2007-09-25       Impact factor: 3.495

10.  Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus.

Authors:  Saori Amaike; Nancy P Keller
Journal:  Eukaryot Cell       Date:  2009-05-01
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  82 in total

1.  Microbial genome mining answers longstanding biosynthetic questions.

Authors:  Jason M Crawford; Jon Clardy
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-01       Impact factor: 11.205

Review 2.  Microbial natural products: molecular blueprints for antitumor drugs.

Authors:  Lesley-Ann Giddings; David J Newman
Journal:  J Ind Microbiol Biotechnol       Date:  2013-09-03       Impact factor: 3.346

Review 3.  Merging chemical ecology with bacterial genome mining for secondary metabolite discovery.

Authors:  Maria I Vizcaino; Xun Guo; Jason M Crawford
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-15       Impact factor: 3.346

Review 4.  Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.

Authors:  Christopher T Walsh; Stuart W Haynes; Brian D Ames; Xue Gao; Yi Tang
Journal:  ACS Chem Biol       Date:  2013-06-04       Impact factor: 5.100

5.  Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes.

Authors:  Inga Hoffmann; Fredrik Jernerén; Ernst H Oliw
Journal:  J Lipid Res       Date:  2014-08-13       Impact factor: 5.922

6.  Ginseng fermented by mycotoxin non-producing Aspergillus niger: ginsenoside analysis and anti-proliferative effects.

Authors:  Zhipeng Li; Geun Eog Ji
Journal:  Food Sci Biotechnol       Date:  2017-07-24       Impact factor: 2.391

7.  Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.

Authors:  Juliane Macheleidt; Kirstin Scherlach; Toni Neuwirth; Wolfgang Schmidt-Heck; Maria Straßburger; Joseph Spraker; Joshua A Baccile; Frank C Schroeder; Nancy P Keller; Christian Hertweck; Thorsten Heinekamp; Axel A Brakhage
Journal:  Mol Microbiol       Date:  2015-03-11       Impact factor: 3.501

Review 8.  Natural products: a continuing source of novel drug leads.

Authors:  Gordon M Cragg; David J Newman
Journal:  Biochim Biophys Acta       Date:  2013-02-18

9.  Identification and characterization of the ZRT, IRT-like protein (ZIP) family genes reveal their involvement in growth and kojic acid production in Aspergillus oryzae.

Authors:  Zhe Zhang; Junxia Fan; Chuannan Long; Bin He; Zhihong Hu; Chunmiao Jiang; Yongkai Li; Long Ma; Jingshang Wen; Xiaojin Zou; Yuan Chen; Zhenxiang Ge; Bin Zeng
Journal:  J Ind Microbiol Biotechnol       Date:  2019-09-20       Impact factor: 3.346

10.  Expression of fusion proteins of Aspergillus terreus reveals a novel allene oxide synthase.

Authors:  Inga Hoffmann; Fredrik Jernerén; Ernst H Oliw
Journal:  J Biol Chem       Date:  2013-03-11       Impact factor: 5.157
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