| Literature DB >> 21384276 |
Valentina Greco1, Elvira Valeria De Marco, Francesca Emanuela Rocca, Ferdinanda Annesi, Donatella Civitelli, Giovanni Provenzano, Patrizia Tarantino, Vittorio Scornaienchi, Franco Pucci, Maria Salsone, Fabiana Novellino, Maurizio Morelli, Sandra Paglionico, Antonio Gambardella, Aldo Quattrone, Grazia Annesi.
Abstract
Iron overload may lead to neurodegenerative disorders such as Parkinson's disease (PD) and alterations of iron-related genes might be involved in the pathogenesis of this disease. The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF). We examined four known polymorphisms, C282Y and H63D in the HFE gene, G258S in the TF gene and S82G in the TFR gene, in 181 sporadic PD patients and 180 controls from Southern Italy to investigate their possible role in susceptibility to PD. No significant differences were found in genotype and allele frequencies between PD and controls for all the polymorphisms studied, suggesting that these variants do not contribute significantly to the risk of PD.Entities:
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Year: 2011 PMID： 21384276 DOI： 10.1007/s10072-011-0504-9
Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307