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Literature DB >> 2136935

Structural basis of the allosteric behaviour of phosphofructokinase.

Abstract

Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.

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Year: 1990 PMID： 2136935 DOI： 10.1038/343140a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

52 in total

1. Thermotoga maritima phosphofructokinases: expression and characterization of two unique enzymes.

Authors: Y R Ding; R S Ronimus; H W Morgan
Journal: J Bacteriol Date: 2001-01 Impact factor: 3.490

2. Kinetic stability as a mechanism for protease longevity.

Authors: E L Cunningham; S S Jaswal; J L Sohl; D A Agard
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

3. Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

Authors: J A Endrizzi; P T Beernink; T Alber; H K Schachman
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

Review 4. Allosteric regulation of catalytic activity: Escherichia coli aspartate transcarbamoylase versus yeast chorismate mutase.

Authors: K Helmstaedt; S Krappmann; G H Braus
Journal: Microbiol Mol Biol Rev Date: 2001-09 Impact factor: 11.056

10. Identification of C-terminal motifs responsible for transmission of inhibition by ATP of mammalian phosphofructokinase, and their contribution to other allosteric effects.

Authors: Oscar H Martínez-Costa; Carmen Hermida; Cristina Sánchez-Martínez; Belén Santamaría; Juan J Aragón
Journal: Biochem J Date: 2004-01-01 Impact factor: 3.857

Structural basis of the allosteric behaviour of phosphofructokinase.

1. Thermotoga maritima phosphofructokinases: expression and characterization of two unique enzymes.

2. Kinetic stability as a mechanism for protease longevity.

3. Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

Review 4. Allosteric regulation of catalytic activity: Escherichia coli aspartate transcarbamoylase versus yeast chorismate mutase.

5. An improved hydrogen bond potential: impact on medium resolution protein structures.

6. Existence of a true phosphofructokinase in Bacillus sphaericus: cloning and sequencing of the pfk gene.

7. A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens.

8. NMR detection of multiple transitions to low-populated states in azurin.

9. Dynamical allosterism in the mechanism of action of DNA mismatch repair protein MutS.

10. Identification of C-terminal motifs responsible for transmission of inhibition by ATP of mammalian phosphofructokinase, and their contribution to other allosteric effects.