Literature DB >> 21366297

A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.

Alexander R Lippert1, Kayvan R Keshari, John Kurhanewicz, Christopher J Chang.   

Abstract

We report a new reaction-based approach for the detection of hydrogen peroxide (H(2)O(2)) using hyperpolarized (13)C magnetic resonance imaging ((13)C MRI) and the H(2)O(2)-mediated oxidation of α-ketoacids to carboxylic acids. (13)C-Benzoylformic acid reacts selectively with H(2)O(2) over other reactive oxygen species to generate (13)C-benzoic acid and can be hyperpolarized using dynamic nuclear polarization, providing a method for dual-frequency detection of H(2)O(2). Phantom images collected using frequency-specific imaging sequences demonstrate the efficacy of this responsive contrast agent to monitor H(2)O(2) at pre-clinical field strengths. The combination of reaction-based detection chemistry and hyperpolarized (13)C MRI provides a potentially powerful new methodology for non-invasive multi-analyte imaging in living systems.

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Year:  2011        PMID： 21366297      PMCID： PMC3060273          DOI： 10.1021/ja111589a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  68 in total

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  31 in total

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2.  Chemiluminescent Measurement of Hydrogen Peroxide in the Exhaled Breath Condensate of Healthy and Asthmatic Adults.

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4.  Chemistry and biology of reactive oxygen species in signaling or stress responses.

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Review 5.  Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond.

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6.  High-resolution optical molecular imaging of changes in choline metabolism in oral neoplasia.

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7.  Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging.

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9.  A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling.

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Review 10.  Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

Authors:  Kayvan R Keshari; David M Wilson
Journal:  Chem Soc Rev       Date:  2013-12-20       Impact factor: 54.564
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