Literature DB >> 26963495

[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.

V N Carroll1, C Truillet, B Shen, R R Flavell, X Shao, M J Evans, H F VanBrocklin, P J H Scott, F T Chin, D M Wilson.   

Abstract

Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).

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Year:  2016        PMID： 26963495      PMCID： PMC4854297          DOI： 10.1039/c6cc00895j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


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