Literature DB >> 21351337

Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

Muthiah Manoharan1, Akin Akinc, Rajendra K Pandey, June Qin, Philipp Hadwiger, Matthias John, Kathy Mills, Klaus Charisse, Martin A Maier, Lubomir Nechev, Emily M Greene, Pradeep S Pallan, Eriks Rozners, Kallanthottathil G Rajeev, Martin Egli.   

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Year:  2011        PMID： 21351337      PMCID： PMC3516925          DOI： 10.1002/anie.201006519

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  31 in total

1.  RNA interference in mammalian cells by chemically-modified RNA.

Authors:  Dwaine A Braasch; Susan Jensen; Yinghui Liu; Kiran Kaur; Khalil Arar; Michael A White; David R Corey
Journal:  Biochemistry       Date:  2003-07-08       Impact factor: 3.162

Review 2.  Organic fluorine: odd man out.

Authors:  Jack D Dunitz
Journal:  Chembiochem       Date:  2004-05-03       Impact factor: 3.164

3.  Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.

Authors:  Veit Hornung; Margit Guenthner-Biller; Carole Bourquin; Andrea Ablasser; Martin Schlee; Satoshi Uematsu; Anne Noronha; Muthiah Manoharan; Shizuo Akira; Antonin de Fougerolles; Stefan Endres; Gunther Hartmann
Journal:  Nat Med       Date:  2005-02-20       Impact factor: 53.440

4.  Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

Authors:  Charles R Allerson; Namir Sioufi; Russell Jarres; Thazha P Prakash; Nishant Naik; Andres Berdeja; Lisa Wanders; Richard H Griffey; Eric E Swayze; Balkrishen Bhat
Journal:  J Med Chem       Date:  2005-02-24       Impact factor: 7.446

5.  Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects.

Authors:  Lina Cekaite; Gro Furset; Eivind Hovig; Mouldy Sioud
Journal:  J Mol Biol       Date:  2006-09-16       Impact factor: 5.469

6.  Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

Authors:  Prasad Dande; Thazha P Prakash; Namir Sioufi; Hans Gaus; Russell Jarres; Andreas Berdeja; Eric E Swayze; Richard H Griffey; Balkrishen Bhat
Journal:  J Med Chem       Date:  2006-03-09       Impact factor: 7.446

7.  Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication.

Authors:  David V Morrissey; Karin Blanchard; Lucinda Shaw; Kristi Jensen; Jennifer A Lockridge; Brent Dickinson; James A McSwiggen; Chandra Vargeese; Keith Bowman; Chris S Shaffer; Barry A Polisky; Shawn Zinnen
Journal:  Hepatology       Date:  2005-06       Impact factor: 17.425

8.  Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses.

Authors:  Mouldy Sioud
Journal:  Eur J Immunol       Date:  2006-05       Impact factor: 5.532

9.  Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing.

Authors:  Jens Harborth; Sayda M Elbashir; Kim Vandenburgh; Heiko Manninga; Stephen A Scaringe; Klaus Weber; Thomas Tuschl
Journal:  Antisense Nucleic Acid Drug Dev       Date:  2003-04

10.  Competition for RISC binding predicts in vitro potency of siRNA.

Authors:  Erich Koller; Stephanie Propp; Heather Murray; Walter Lima; Balkrishen Bhat; Thaza P Prakash; Charles R Allerson; Eric E Swayze; Eric G Marcusson; Nicholas M Dean
Journal:  Nucleic Acids Res       Date:  2006-08-31       Impact factor: 16.971
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  51 in total

1.  The conformationally constrained N-methanocarba-dT analogue adopts an unexpected C4'-exo sugar pucker in the structure of a DNA hairpin.

Authors:  Pradeep S Pallan; Victor E Marquez; Martin Egli
Journal:  Biochemistry       Date:  2012-03-20       Impact factor: 3.162

2.  2'Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors.

Authors:  Youngju Lee; Johannes H Urban; Li Xu; Bruce A Sullenger; Jaewoo Lee
Journal:  Nucleic Acid Ther       Date:  2016-01-20       Impact factor: 5.486

3.  Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.

Authors:  Punit P Seth; Jinghua Yu; Ali Jazayeri; Pradeep S Pallan; Charles R Allerson; Michael E Østergaard; Fengwu Liu; Piet Herdewijn; Martin Egli; Eric E Swayze
Journal:  J Org Chem       Date:  2012-05-18       Impact factor: 4.354

4.  Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

Authors:  Martin Egli; Pradeep S Pallan; Charles R Allerson; Thazha P Prakash; Andres Berdeja; Jinghua Yu; Sam Lee; Andrew Watt; Hans Gaus; Balkrishen Bhat; Eric E Swayze; Punit P Seth
Journal:  J Am Chem Soc       Date:  2011-09-22       Impact factor: 15.419

Review 5.  Antisense technology: an overview and prospectus.

Authors:  Stanley T Crooke; Brenda F Baker; Rosanne M Crooke; Xue-Hai Liang
Journal:  Nat Rev Drug Discov       Date:  2021-03-24       Impact factor: 84.694

Review 6.  The chemical evolution of oligonucleotide therapies of clinical utility.

Authors:  Anastasia Khvorova; Jonathan K Watts
Journal:  Nat Biotechnol       Date:  2017-02-27       Impact factor: 54.908

7.  Single-stranded microRNA mimics.

Authors:  Guillaume Chorn; Molly Klein-McDowell; Lihong Zhao; Matthew A Saunders; W Michael Flanagan; Aarron T Willingham; Lee P Lim
Journal:  RNA       Date:  2012-08-21       Impact factor: 4.942

8.  2'-Fluoro RNA shows increased Watson-Crick H-bonding strength and stacking relative to RNA: evidence from NMR and thermodynamic data.

Authors:  Amritraj Patra; Michael Paolillo; Klaus Charisse; Muthiah Manoharan; Eriks Rozners; Martin Egli
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-10       Impact factor: 15.336

9.  Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

Authors:  Uday Ghanty; Erik Fostvedt; Rachel Valenzuela; Peter A Beal; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

Review 10.  RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials.

Authors:  Eunice L Lozada-Delgado; Nilmary Grafals-Ruiz; Pablo E Vivas-Mejía
Journal:  Life Sci       Date:  2017-08-31       Impact factor: 5.037
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