Literature DB >> 21350497

The long and winding road from correlation to causation.

Michel Georges.   

Abstract

Follow-up studies of a Crohn's disease risk locus encompassing IRGM have revealed unexpected complexity. A new study shows that a synonymous variant in the IRGM coding region alters a binding site for miR-196 and modulates IRGM-dependent autophagy, adding to the list of possible mechanisms by which this locus influences disease risk.

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Year:  2011        PMID： 21350497     DOI： 10.1038/ng0311-180

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  Demonstrating polymorphic miRNA-mediated gene regulation in vivo: application to the g+6223G->A mutation of Texel sheep.

Authors:  Haruko Takeda; Carole Charlier; Frédéric Farnir; Michel Georges
Journal:  RNA       Date:  2010-08-02       Impact factor: 4.942

2.  Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease.

Authors:  Yukihide Momozawa; Myriam Mni; Kayo Nakamura; Wouter Coppieters; Sven Almer; Leila Amininejad; Isabelle Cleynen; Jean-Frédéric Colombel; Peter de Rijk; Olivier Dewit; Yigael Finkel; Miquel A Gassull; Dirk Goossens; Debby Laukens; Marc Lémann; Cécile Libioulle; Colm O'Morain; Catherine Reenaers; Paul Rutgeerts; Curt Tysk; Diana Zelenika; Mark Lathrop; Jurgen Del-Favero; Jean-Pierre Hugot; Martine de Vos; Denis Franchimont; Severine Vermeire; Edouard Louis; Michel Georges
Journal:  Nat Genet       Date:  2010-12-12       Impact factor: 38.330

3.  A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.

Authors:  Patrick Brest; Pierre Lapaquette; Mouloud Souidi; Kevin Lebrigand; Annabelle Cesaro; Valérie Vouret-Craviari; Bernard Mari; Pascal Barbry; Jean-François Mosnier; Xavier Hébuterne; Annick Harel-Bellan; Baharia Mograbi; Arlette Darfeuille-Michaud; Paul Hofman
Journal:  Nat Genet       Date:  2011-01-30       Impact factor: 38.330

4.  Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Authors:  Sudha B Singh; Alexander S Davis; Gregory A Taylor; Vojo Deretic
Journal:  Science       Date:  2006-08-03       Impact factor: 47.728

5.  Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Authors:  John D Rioux; Ramnik J Xavier; Kent D Taylor; Mark S Silverberg; Philippe Goyette; Alan Huett; Todd Green; Petric Kuballa; M Michael Barmada; Lisa Wu Datta; Yin Yao Shugart; Anne M Griffiths; Stephan R Targan; Andrew F Ippoliti; Edmond-Jean Bernard; Ling Mei; Dan L Nicolae; Miguel Regueiro; L Philip Schumm; A Hillary Steinhart; Jerome I Rotter; Richard H Duerr; Judy H Cho; Mark J Daly; Steven R Brant
Journal:  Nat Genet       Date:  2007-04-15       Impact factor: 38.330

6.  Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

Authors:  Steven A McCarroll; Alan Huett; Petric Kuballa; Shannon D Chilewski; Aimee Landry; Philippe Goyette; Michael C Zody; Jennifer L Hall; Steven R Brant; Judy H Cho; Richard H Duerr; Mark S Silverberg; Kent D Taylor; John D Rioux; David Altshuler; Mark J Daly; Ramnik J Xavier
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

7.  A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Authors:  Jochen Hampe; Andre Franke; Philip Rosenstiel; Andreas Till; Markus Teuber; Klaus Huse; Mario Albrecht; Gabriele Mayr; Francisco M De La Vega; Jason Briggs; Simone Günther; Natalie J Prescott; Clive M Onnie; Robert Häsler; Bence Sipos; Ulrich R Fölsch; Thomas Lengauer; Matthias Platzer; Christopher G Mathew; Michael Krawczak; Stefan Schreiber
Journal:  Nat Genet       Date:  2006-12-31       Impact factor: 38.330

8.  Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.

Authors:  Natalie J Prescott; Katherine M Dominy; Michiaki Kubo; Cathryn M Lewis; Sheila A Fisher; Richard Redon; Ni Huang; Barbara E Stranger; Katarzyna Blaszczyk; Barry Hudspith; Gareth Parkes; Naoya Hosono; Keiko Yamazaki; Clive M Onnie; Alastair Forbes; Emmanouil T Dermitzakis; Yusuke Nakamura; John C Mansfield; Jeremy Sanderson; Matthew E Hurles; Roland G Roberts; Christopher G Mathew
Journal:  Hum Mol Genet       Date:  2010-01-27       Impact factor: 6.150

9.  Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Authors:  Miles Parkes; Jeffrey C Barrett; Natalie J Prescott; Mark Tremelling; Carl A Anderson; Sheila A Fisher; Roland G Roberts; Elaine R Nimmo; Fraser R Cummings; Dianne Soars; Hazel Drummond; Charlie W Lees; Saud A Khawaja; Richard Bagnall; Denis A Burke; Catherine E Todhunter; Tariq Ahmad; Clive M Onnie; Wendy McArdle; David Strachan; Graeme Bethel; Claire Bryan; Cathryn M Lewis; Panos Deloukas; Alastair Forbes; Jeremy Sanderson; Derek P Jewell; Jack Satsangi; John C Mansfield; Lon Cardon; Christopher G Mathew
Journal:  Nat Genet       Date:  2007-06-06       Impact factor: 38.330

Review 10.  Unveiling the roles of autophagy in innate and adaptive immunity.

Authors:  Beth Levine; Vojo Deretic
Journal:  Nat Rev Immunol       Date:  2007-10       Impact factor: 53.106
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  6 in total

Review 1.  Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases.

Authors:  Xu-Jie Zhou; Hong Zhang
Journal:  Autophagy       Date:  2012-08-14       Impact factor: 16.016

2.  Emerging views of mitophagy in immunity and autoimmune diseases.

Authors:  Ye Xu; Jun Shen; Zhihua Ran
Journal:  Autophagy       Date:  2019-04-21       Impact factor: 16.016

3.  Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification.

Authors:  Laura L Faye; Mitchell J Machiela; Peter Kraft; Shelley B Bull; Lei Sun
Journal:  PLoS Genet       Date:  2013-08-08       Impact factor: 5.917

Review 4.  Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium.

Authors:  Tiago Nunes; Claudio Bernardazzi; Heitor S de Souza
Journal:  Biomed Res Int       Date:  2014-07-14       Impact factor: 3.411

5.  Prioritization of genetic variants in the microRNA regulome as functional candidates in genome-wide association studies.

Authors:  Brendan Bulik-Sullivan; Sara Selitsky; Praveen Sethupathy
Journal:  Hum Mutat       Date:  2013-05-08       Impact factor: 4.878

6.  Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer.

Authors:  Nicola Currey; Zeenat Jahan; C Elizabeth Caldon; Phuong N Tran; Fahad Benthani; Penelope De Lacavalerie; Daniel L Roden; Brian S Gloss; Claudia Campos; Elaine G Bean; Amanda Bullman; Saskia Reibe-Pal; Marcel E Dinger; Mark A Febbraio; Stephen J Clarke; Jane E Dahlstrom; Maija R J Kohonen-Corish
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2019-03-02
  6 in total

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