| Literature DB >> 17435756 |
John D Rioux1, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta, Yin Yao Shugart, Anne M Griffiths, Stephan R Targan, Andrew F Ippoliti, Edmond-Jean Bernard, Ling Mei, Dan L Nicolae, Miguel Regueiro, L Philip Schumm, A Hillary Steinhart, Jerome I Rotter, Richard H Duerr, Judy H Cho, Mark J Daly, Steven R Brant.
Abstract
We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R associations, we identified strong and significantly replicated associations (combined P < 10(-10)) with an intergenic region on 10q21.1 and a coding variant in ATG16L1, the latter of which was also recently reported by another group. We also report strong associations with independent replication to variation in the genomic regions encoding PHOX2B, NCF4 and a predicted gene on 16q24.1 (FAM92B). Finally, we demonstrate that ATG16L1 is expressed in intestinal epithelial cell lines and that functional knockdown of this gene abrogates autophagy of Salmonella typhimurium. Together, these findings suggest that autophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease.Entities:
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Year: 2007 PMID： 17435756 PMCID： PMC2757939 DOI： 10.1038/ng2032
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330