Literature DB >> 17554261

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Miles Parkes1, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars, Hazel Drummond, Charlie W Lees, Saud A Khawaja, Richard Bagnall, Denis A Burke, Catherine E Todhunter, Tariq Ahmad, Clive M Onnie, Wendy McArdle, David Strachan, Graeme Bethel, Claire Bryan, Cathryn M Lewis, Panos Deloukas, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, Jack Satsangi, John C Mansfield, Lon Cardon, Christopher G Mathew.   

Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

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Year:  2007        PMID： 17554261      PMCID： PMC2628541          DOI： 10.1038/ng2061

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

1.  Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.

Authors:  J D Rioux; M J Daly; M S Silverberg; K Lindblad; H Steinhart; Z Cohen; T Delmonte; K Kocher; K Miller; S Guschwan; E J Kulbokas; S O'Leary; E Winchester; K Dewar; T Green; V Stone; C Chow; A Cohen; D Langelier; G Lapointe; D Gaudet; J Faith; N Branco; S B Bull; R S McLeod; A M Griffiths; A Bitton; G R Greenberg; E S Lander; K A Siminovitch; T J Hudson
Journal:  Nat Genet       Date:  2001-10       Impact factor: 38.330

2.  A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Authors:  Richard H Duerr; Kent D Taylor; Steven R Brant; John D Rioux; Mark S Silverberg; Mark J Daly; A Hillary Steinhart; Clara Abraham; Miguel Regueiro; Anne Griffiths; Themistocles Dassopoulos; Alain Bitton; Huiying Yang; Stephan Targan; Lisa Wu Datta; Emily O Kistner; L Philip Schumm; Annette T Lee; Peter K Gregersen; M Michael Barmada; Jerome I Rotter; Dan L Nicolae; Judy H Cho
Journal:  Science       Date:  2006-10-26       Impact factor: 47.728

3.  Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Authors:  Sudha B Singh; Alexander S Davis; Gregory A Taylor; Vojo Deretic
Journal:  Science       Date:  2006-08-03       Impact factor: 47.728

4.  NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue.

Authors:  O Pabst; R Förster; M Lipp; H Engel; H H Arnold
Journal:  EMBO J       Date:  2000-05-02       Impact factor: 11.598

5.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.

Authors:  J P Hugot; M Chamaillard; H Zouali; S Lesage; J P Cézard; J Belaiche; S Almer; C Tysk; C A O'Morain; M Gassull; V Binder; Y Finkel; A Cortot; R Modigliani; P Laurent-Puig; C Gower-Rousseau; J Macry; J F Colombel; M Sahbatou; G Thomas
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

6.  A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.

Authors:  Y Ogura; D K Bonen; N Inohara; D L Nicolae; F F Chen; R Ramos; H Britton; T Moran; R Karaliuskas; R H Duerr; J P Achkar; S R Brant; T M Bayless; B S Kirschner; S B Hanauer; G Nuñez; J H Cho
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

7.  Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease.

Authors:  A Zwiers; D Seegers; R Heijmans; A Koch; J Hampe; S Nikolaus; A S Peña; S Schreiber; G Bouma
Journal:  Genes Immun       Date:  2004-12       Impact factor: 2.676

8.  The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.

Authors:  Cemalettin Bekpen; Julia P Hunn; Christoph Rohde; Iana Parvanova; Libby Guethlein; Diane M Dunn; Eva Glowalla; Maria Leptin; Jonathan C Howard
Journal:  Genome Biol       Date:  2005-10-31       Impact factor: 13.583

9.  Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.

Authors:  C M Collazo; G S Yap; G D Sempowski; K C Lusby; L Tessarollo; G F Vande Woude; A Sher; G A Taylor
Journal:  J Exp Med       Date:  2001-07-16       Impact factor: 14.307

10.  Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.

Authors:  Cécile Libioulle; Edouard Louis; Sarah Hansoul; Cynthia Sandor; Frédéric Farnir; Denis Franchimont; Séverine Vermeire; Olivier Dewit; Martine de Vos; Anna Dixon; Bruno Demarche; Ivo Gut; Simon Heath; Mario Foglio; Liming Liang; Debby Laukens; Myriam Mni; Diana Zelenika; André Van Gossum; Paul Rutgeerts; Jacques Belaiche; Mark Lathrop; Michel Georges
Journal:  PLoS Genet       Date:  2007-03-05       Impact factor: 5.917
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  471 in total

Review 1.  Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

Authors:  Amrita Kabi; Kourtney P Nickerson; Craig R Homer; Christine McDonald
Journal:  Inflamm Bowel Dis       Date:  2011-09-20       Impact factor: 5.325

2.  [Genetics of common chronic inflammatory skin diseases : An update on atopic dermatitis and psoriasis].

Authors:  E Rodríguez; K Eyerich; S Weidinger
Journal:  Hautarzt       Date:  2011-02       Impact factor: 0.751

Review 3.  Expression and functional importance of innate immune receptors by intestinal epithelial cells.

Authors:  Rute Marques; Ivo G Boneca
Journal:  Cell Mol Life Sci       Date:  2011-10-08       Impact factor: 9.261

Review 4.  Crohn disease: a current perspective on genetics, autophagy and immunity.

Authors:  Thaddeus S Stappenbeck; John D Rioux; Atsushi Mizoguchi; Tatsuya Saitoh; Alan Huett; Arlette Darfeuille-Michaud; Tom Wileman; Noboru Mizushima; Simon Carding; Shizuo Akira; Miles Parkes; Ramnik J Xavier
Journal:  Autophagy       Date:  2011-04-01       Impact factor: 16.016

5.  Inflammatory bowel disease in Korea: epidemiological, genomic, clinical, and therapeutic characteristics.

Authors:  Eun Soo Kim; Won Ho Kim
Journal:  Gut Liver       Date:  2010-03-25       Impact factor: 4.519

6.  Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

Authors:  Marylyn D Ritchie; Joshua C Denny; Dana C Crawford; Andrea H Ramirez; Justin B Weiner; Jill M Pulley; Melissa A Basford; Kristin Brown-Gentry; Jeffrey R Balser; Daniel R Masys; Jonathan L Haines; Dan M Roden
Journal:  Am J Hum Genet       Date:  2010-04-01       Impact factor: 11.025

Review 7.  Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.

Authors:  Altin Gjymishka; Roxana M Coman; Todd M Brusko; Sarah C Glover
Journal:  Immunotherapy       Date:  2013-12       Impact factor: 4.196

Review 8.  Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease.

Authors:  Arthur Kaser; Richard S Blumberg
Journal:  Semin Immunol       Date:  2009-02-23       Impact factor: 11.130

9.  Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

Authors:  P Goyette; C Lefebvre; A Ng; S R Brant; J H Cho; R H Duerr; M S Silverberg; K D Taylor; A Latiano; G Aumais; C Deslandres; G Jobin; V Annese; M J Daly; R J Xavier; J D Rioux
Journal:  Mucosal Immunol       Date:  2008-01-16       Impact factor: 7.313

10.  Detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is unrelated to the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B).

Authors:  James P Dalton; Alan Desmond; Fergus Shanahan; Colin Hill
Journal:  Med Microbiol Immunol       Date:  2014-02-13       Impact factor: 3.402
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