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Literature DB >> 21327279

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler.

Abstract

We report a synthetic biology strategy for rapid genetic manipulation of natural product biosynthetic pathways. Based on DNA assembler, this method synthesizes the entire expression vector containing the target biosynthetic pathway and the genetic elements required for DNA maintenance and replication in various hosts in a single-step manner through yeast homologous recombination, offering unprecedented flexibility and versatility in pathway manipulations.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Biological Products

Year: 2011 PMID： 21327279 PMCID： PMC4320646 DOI： 10.1039/c0mb00338g

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

34 in total

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3. Regulation of the biosynthesis of the macrolide antibiotic spiramycin in Streptomyces ambofaciens.

Authors: Fatma Karray; Emmanuelle Darbon; Hoang Chuong Nguyen; Josette Gagnat; Jean-Luc Pernodet
Journal: J Bacteriol Date: 2010-09-03 Impact factor: 3.490

4. Recovery and potential utility of YACs as circular YACs/BACs.

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5. A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2).

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Journal: Arch Microbiol Date: 2006-09-29 Impact factor: 2.552

6. Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.

Authors: Tomomi Moriguchi; Yuichiro Kezuka; Takamasa Nonaka; Yutaka Ebizuka; Isao Fujii
Journal: J Biol Chem Date: 2010-03-19 Impact factor: 5.157

7. Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective.

Authors: Nelly Traitcheva; Holger Jenke-Kodama; Jing He; Elke Dittmann; Christian Hertweck
Journal: Chembiochem Date: 2007-10-15 Impact factor: 3.164

8. Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.

Authors: Takuya Ito; Niran Roongsawang; Norifumi Shirasaka; Wanli Lu; Patricia M Flatt; Noer Kasanah; Cristobal Miranda; Taifo Mahmud
Journal: Chembiochem Date: 2009-09-04 Impact factor: 3.164

9. A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin.

Authors: Silke C Wenzel; Helge B Bode; Irene Kochems; Rolf Müller
Journal: Chembiochem Date: 2008-11-03 Impact factor: 3.164

10. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways.

Authors: Zengyi Shao; Hua Zhao; Huimin Zhao
Journal: Nucleic Acids Res Date: 2008-12-12 Impact factor: 16.971

39 in total

1. Construction and engineering of large biochemical pathways via DNA assembler.

Authors: Zengyi Shao; Huimin Zhao
Journal: Methods Mol Biol Date: 2013

Review 2. Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

Authors: Yuriy Rebets; Elke Brötz; Bogdan Tokovenko; Andriy Luzhetskyy
Journal: J Ind Microbiol Biotechnol Date: 2013-10-15 Impact factor: 3.346

Review 3. DNA assembly techniques for next-generation combinatorial biosynthesis of natural products.

Authors: Ryan E Cobb; Jonathan C Ning; Huimin Zhao
Journal: J Ind Microbiol Biotechnol Date: 2013-10-15 Impact factor: 3.346

Review 4. Recent advances in natural product discovery.

Authors: Yunzi Luo; Ryan E Cobb; Huimin Zhao
Journal: Curr Opin Biotechnol Date: 2014-09-26 Impact factor: 9.740

Review 5. Engineering biological systems toward a sustainable bioeconomy.

Authors: Mateus Schreiner Garcez Lopes
Journal: J Ind Microbiol Biotechnol Date: 2015-04-07 Impact factor: 3.346

Review 6. Heterologous expression-facilitated natural products' discovery in actinomycetes.

Authors: Min Xu; Gerard D Wright
Journal: J Ind Microbiol Biotechnol Date: 2018-11-16 Impact factor: 3.346

7. Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

Authors: Meng Wang; Mirko Beissner; Huimin Zhao
Journal: Chem Biol Date: 2014-01-09

Review 8. Using natural products for drug discovery: the impact of the genomics era.

Authors: Mingzi M Zhang; Yuan Qiao; Ee Lui Ang; Huimin Zhao
Journal: Expert Opin Drug Discov Date: 2017-03-14 Impact factor: 6.098

Review 9. Genetic platforms for heterologous expression of microbial natural products.

Authors: Jia Jia Zhang; Xiaoyu Tang; Bradley S Moore
Journal: Nat Prod Rep Date: 2019-06-14 Impact factor: 13.423

10. Reinvigorating natural product combinatorial biosynthesis with synthetic biology.

Authors: Eunji Kim; Bradley S Moore; Yeo Joon Yoon
Journal: Nat Chem Biol Date: 2015-09 Impact factor: 15.040