| Literature DB >> 21326937 |
Jose-Luis Adrio1, Arnold L Demain.
Abstract
A revolution in industrial microbiology was sparked by the discoveries of ther double-stranded structure of DNA and the development of recombinant DNA technology. Traditional industrial microbiology was merged with molecular biology to yield improved recombinant processes for the industrial production of primary and secondary metabolites, protein biopharmaceuticals and industrial enzymes. Novel genetic techniques such as metabolic engineering, combinatorial biosynthesis and molecular breeding techniques and their modifications are contributing greatly to the development of improved industrial processes. In addition, functional genomics, proteomics and metabolomics are being exploited for the discovery of novel valuable small molecules for medicine as well as enzymes for catalysis. The sequencing of industrial microbal genomes is being carried out which bodes well for future process improvement and discovery of new industrial products.Keywords: antibiotics; antitumor agents; biopharmaceuticals; cholesterol-lowering agents; enzymes; genetic recombination; industrial products; primary metabolites; secondary metabolites
Mesh：
Substances：
Year: 2009 PMID： 21326937 PMCID： PMC3026452 DOI： 10.4161/bbug.1.2.10484
Source DB: PubMed Journal: Bioeng Bugs ISSN： 1949-1018