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Literature DB >> 21296451

Peto's Paradox: evolution's prescription for cancer prevention.

Abstract

The evolution of multicellularity required the suppression of cancer. If every cell has some chance of becoming cancerous, large, long-lived organisms should have an increased risk of developing cancer compared with small, short-lived organisms. The lack of correlation between body size and cancer risk is known as Peto's paradox. Animals with 1000 times more cells than humans do not exhibit an increased cancer risk, suggesting that natural mechanisms can suppress cancer 1000 times more effectively than is done in human cells. Because cancer has proven difficult to cure, attention has turned to cancer prevention. In this review, similar to pharmaceutical companies mining natural products, we seek to understand how evolution has suppressed cancer to develop ultimately improved cancer prevention in humans.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2011 PMID： 21296451 PMCID： PMC3060950 DOI： 10.1016/j.tree.2011.01.002

Source DB: PubMed Journal: Trends Ecol Evol ISSN： 0169-5347 Impact factor: 17.712

69 in total

1. Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.

Authors: O Humbert; S Fiumicino; G Aquilina; P Branch; S Oda; A Zijno; P Karran; M Bignami
Journal: Carcinogenesis Date: 1999-02 Impact factor: 4.944

2. Mutation selection and the natural history of cancer.

Authors: J Cairns
Journal: Nature Date: 1975-05-15 Impact factor: 49.962

Review 3. Body size, energy metabolism and lifespan.

Authors: John R Speakman
Journal: J Exp Biol Date: 2005-05 Impact factor: 3.312

4. p53 mutant mice that display early ageing-associated phenotypes.

Authors: Stuart D Tyner; Sundaresan Venkatachalam; Jene Choi; Stephen Jones; Nader Ghebranious; Herbert Igelmann; Xiongbin Lu; Gabrielle Soron; Benjamin Cooper; Cory Brayton; Sang Hee Park; Timothy Thompson; Gerard Karsenty; Allan Bradley; Lawrence A Donehower
Journal: Nature Date: 2002-01-03 Impact factor: 49.962

Review 5. Cancer as an evolutionary and ecological process.

Authors: Lauren M F Merlo; John W Pepper; Brian J Reid; Carlo C Maley
Journal: Nat Rev Cancer Date: 2006-11-16 Impact factor: 60.716

6. A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates.

Authors: Peter Calabrese; Darryl Shibata
Journal: BMC Cancer Date: 2010-01-05 Impact factor: 4.430

7. Estimating mutation parameters, population history and genealogy simultaneously from temporally spaced sequence data.

Authors: Alexei J Drummond; Geoff K Nicholls; Allen G Rodrigo; Wiremu Solomon
Journal: Genetics Date: 2002-07 Impact factor: 4.562

8. Adaptive immunity maintains occult cancer in an equilibrium state.

Authors: Catherine M Koebel; William Vermi; Jeremy B Swann; Nadeen Zerafa; Scott J Rodig; Lloyd J Old; Mark J Smyth; Robert D Schreiber
Journal: Nature Date: 2007-11-18 Impact factor: 49.962

9. Toward a genetics of cancer resistance.

Authors: George Klein
Journal: Proc Natl Acad Sci U S A Date: 2009-01-07 Impact factor: 11.205

10. A simple technique for quantifying apoptosis in 96-well plates.

Authors: Deborah Ribble; Nathaniel B Goldstein; David A Norris; Yiqun G Shellman
Journal: BMC Biotechnol Date: 2005-05-10 Impact factor: 2.563

121 in total

1. Identification of African Elephant Polyomavirus in wild elephants and the creation of a vector expressing its viral tumor antigens to transform elephant primary cells.

Authors: Virginia R Pearson; Jens B Bosse; Orkide O Koyuncu; Julian Scherer; Cristhian Toruno; Rosann Robinson; Lisa M Abegglen; Joshua D Schiffman; Lynn W Enquist; Glenn F Rall
Journal: PLoS One Date: 2021-02-05 Impact factor: 3.240

Peto's Paradox: evolution's prescription for cancer prevention.

1. Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.

2. Mutation selection and the natural history of cancer.

Review 3. Body size, energy metabolism and lifespan.

4. p53 mutant mice that display early ageing-associated phenotypes.

Review 5. Cancer as an evolutionary and ecological process.

6. A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates.

7. Estimating mutation parameters, population history and genealogy simultaneously from temporally spaced sequence data.

8. Adaptive immunity maintains occult cancer in an equilibrium state.

9. Toward a genetics of cancer resistance.

10. A simple technique for quantifying apoptosis in 96-well plates.

1. Identification of African Elephant Polyomavirus in wild elephants and the creation of a vector expressing its viral tumor antigens to transform elephant primary cells.

Review 2. The sociality-health-fitness nexus: synthesis, conclusions and future directions.

Review 3. Maternal-fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer.

Review 4. Evolutionary medicine: its scope, interest and potential.

Review 5. Cancer in light of experimental evolution.

Review 6. Cellular hyperproliferation and cancer as evolutionary variables.

Review 7. A comparative cellular and molecular biology of longevity database.

8. Blood cell telomere lengths and shortening rates of chimpanzee and human females.

9. The evolution of lifespan and age-dependent cancer risk.

Review 10. How ageing processes influence cancer.