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Literature DB >> 19129501

Toward a genetics of cancer resistance.

Abstract

Two of three humans never get cancer. Even the majority of heavy smokers remain cancer free. Is this a matter of chance, or are there cancer-resistant genotypes? Based on the evidence discussed, it would appear that evolution has favored a limited number of relatively common resistance genes that may nip incipient cancerous foci in the bud, i.e., to stop them at their inception. It is further suggested that resistance genes may act at the level of tissue organization in a dominant fashion.

Entities: Disease Species

Mesh：

Year: 2009 PMID： 19129501 PMCID： PMC2630080 DOI： 10.1073/pnas.0811616106

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

50 in total

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Authors: Cindy S Ma; Kim E Nichols; Stuart G Tangye
Journal: Annu Rev Immunol Date: 2007 Impact factor: 28.527

2. Cancer is a somatic cell pregnancy.

Authors: Lloyd J Old
Journal: Cancer Immun Date: 2007-11-06

Review 3. Cancer resistance genes in mice: models for the study of tumour modifiers.

Authors: A Balmain; H Nagase
Journal: Trends Genet Date: 1998-04 Impact factor: 11.639

4. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.

Authors: Takashi Sakatani; Atsushi Kaneda; Christine A Iacobuzio-Donahue; Mark G Carter; Sten de Boom Witzel; Hideyuki Okano; Minoru S H Ko; Rolf Ohlsson; Dan L Longo; Andrew P Feinberg
Journal: Science Date: 2005-02-24 Impact factor: 47.728

5. Human papillomavirus and lower genital neoplasia in renal transplant patients.

Authors: R Halpert; R G Fruchter; A Sedlis; K Butt; J G Boyce; F H Sillman
Journal: Obstet Gynecol Date: 1986-08 Impact factor: 7.661

6. Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy.

Authors: George N Naumov; Ian C MacDonald; Pascal M Weinmeister; Nancy Kerkvliet; Kishore V Nadkarni; Sylvia M Wilson; Vincent L Morris; Alan C Groom; Ann F Chambers
Journal: Cancer Res Date: 2002-04-01 Impact factor: 12.701

7. Global loss of imprinting leads to widespread tumorigenesis in adult mice.

Authors: Teresa M Holm; Laurie Jackson-Grusby; Tobias Brambrink; Yasuhiro Yamada; William M Rideout; Rudolf Jaenisch
Journal: Cancer Cell Date: 2005-10 Impact factor: 31.743

8. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.

Authors: Fei Wang; Rhonda K Hansen; Derek Radisky; Toshiyuki Yoneda; Mary Helen Barcellos-Hoff; Ole W Petersen; Eva A Turley; Mina J Bissell
Journal: J Natl Cancer Inst Date: 2002-10-02 Impact factor: 13.506

Review 9. Role of genetic and epigenetic changes in Burkitt lymphoma.

Authors: Mikael S Lindström; Klas G Wiman
Journal: Semin Cancer Biol Date: 2002-10 Impact factor: 15.707

10. Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.

Authors: Elisabeth Amyes; Chris Hatton; Damien Montamat-Sicotte; Nancy Gudgeon; Alan B Rickinson; Andrew J McMichael; Margaret F C Callan
Journal: J Exp Med Date: 2003-09-15 Impact factor: 14.307

24 in total

1. The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity.

Authors: Pratima Basak; Rachelle Dillon; Heather Leslie; Afshin Raouf; Michael R A Mowat
Journal: BMC Cancer Date: 2015-09-09 Impact factor: 4.430

2. Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.

Authors: Francesco Acquati; Sabrina Bertilaccio; Annalisa Grimaldi; Laura Monti; Raffaella Cinquetti; Paolo Bonetti; Marta Lualdi; Laura Vidalino; Marco Fabbri; Maria Grazia Sacco; Nico van Rooijen; Paola Campomenosi; Davide Vigetti; Alberto Passi; Cristina Riva; Carlo Capella; Francesca Sanvito; Claudio Doglioni; Laura Gribaldo; Paolo Macchi; Antonio Sica; Douglas M Noonan; Paolo Ghia; Roberto Taramelli
Journal: Proc Natl Acad Sci U S A Date: 2010-12-28 Impact factor: 11.205

3. Cancer resistance and Peto's paradox.

Authors: Anders Bredberg
Journal: Proc Natl Acad Sci U S A Date: 2009-04-29 Impact factor: 11.205

4. The modulatory effect of cell–cell contact on the tumourigenic potential of pre-malignant epithelial cells: a computational exploration.

Authors: D C Walker; J Southgate
Journal: J R Soc Interface Date: 2012-11-08 Impact factor: 4.118

5. Breast and other cancer dormancy as a therapeutic endpoint: speculative recombinant T cell receptor ligand (RTL) adjuvant therapy worth considering?

Authors: Tibor Bakács; Jitendra N Mehrishi
Journal: BMC Cancer Date: 2010-06-02 Impact factor: 4.430

6. Differential inhibition of trastuzumab- and cetuximab-induced cytotoxicity of cancer cells by immunoglobulin G1 expressing different GM allotypes.

Authors: A M Namboodiri; J P Pandey
Journal: Clin Exp Immunol Date: 2011-12 Impact factor: 4.330