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Literature DB >> 21289622

Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

W Sadee¹, D Wang, A C Papp, J K Pinsonneault, R M Smith, R A Moyer, A D Johnson.

Abstract

The use of pharmacogenomic biomarkers can enhance treatment outcomes. Regulatory polymorphisms are promising biomarkers that have proven difficult to uncover. They come in two flavors: those that affect transcription (regulatory single-nucleotide polymorphisms (rSNPs)) and those that affect RNA functions such as splicing, turnover, and translation (termed structural RNA SNPs (srSNPs)). This review focuses on the role of srSNPs in drug metabolism, transport, and response. An understanding of the nature and diversity of srSNPs and rSNPs enables clinical scientists to evaluate genetic biomarkers.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 21289622 PMCID： PMC3251919 DOI： 10.1038/clpt.2010.314

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

50 in total

1. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

Authors: Ying Zhang; Danxin Wang; Andrew D Johnson; Audrey C Papp; Wolfgang Sadée
Journal: J Biol Chem Date: 2005-07-26 Impact factor: 5.157

2. Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors.

Authors: Julia K Pinsonneault; Audrey C Papp; Wolfgang Sadée
Journal: Hum Mol Genet Date: 2006-08-07 Impact factor: 6.150

3. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors: Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal: Proc Natl Acad Sci U S A Date: 2009-05-27 Impact factor: 11.205

4. Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

Authors: Andrew D Johnson; Ying Zhang; Audrey C Papp; Julia K Pinsonneault; Jeong-Eun Lim; David Saffen; Zunyan Dai; Danxin Wang; Wolfgang Sadée
Journal: Pharmacogenet Genomics Date: 2008-09 Impact factor: 2.089

5. Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics.

Authors: Mikko Niemi; Katja A Arnold; Janne T Backman; Marja K Pasanen; Ute Gödtel-Armbrust; Leszek Wojnowski; Ulrich M Zanger; Pertti J Neuvonen; Michel Eichelbaum; Kari T Kivistö; Thomas Lang
Journal: Pharmacogenet Genomics Date: 2006-11 Impact factor: 2.089

6. Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.

Authors: Robert A Moyer; Danxin Wang; Audrey C Papp; Ryan M Smith; Linda Duque; Deborah C Mash; Wolfgang Sadee
Journal: Neuropsychopharmacology Date: 2010-12-08 Impact factor: 7.853

7. Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

Authors: Tanja Zeller; Philipp Wild; Silke Szymczak; Maxime Rotival; Arne Schillert; Raphaele Castagne; Seraya Maouche; Marine Germain; Karl Lackner; Heidi Rossmann; Medea Eleftheriadis; Christoph R Sinning; Renate B Schnabel; Edith Lubos; Detlev Mennerich; Werner Rust; Claire Perret; Carole Proust; Viviane Nicaud; Joseph Loscalzo; Norbert Hübner; David Tregouet; Thomas Münzel; Andreas Ziegler; Laurence Tiret; Stefan Blankenberg; François Cambien
Journal: PLoS One Date: 2010-05-18 Impact factor: 3.240

8. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.

Authors: Jubao Duan; Mark S Wainwright; Josep M Comeron; Naruya Saitou; Alan R Sanders; Joel Gelernter; Pablo V Gejman
Journal: Hum Mol Genet Date: 2003-02-01 Impact factor: 6.150

9. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.

Authors: Nicholas T Ingolia; Sina Ghaemmaghami; John R S Newman; Jonathan S Weissman
Journal: Science Date: 2009-02-12 Impact factor: 47.728

10. microRNAs and genetic diseases.

Authors: Nicola Meola; Vincenzo Alessandro Gennarino; Sandro Banfi
Journal: Pathogenetics Date: 2009-11-04

23 in total

1. What is a functional genetic polymorphism? Defining classes of functionality.

Authors: Paul R Albert
Journal: J Psychiatry Neurosci Date: 2011-11 Impact factor: 6.186

2. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes.

Authors: Xiaoling Zhang; Andrew D Johnson; Audrey E Hendricks; Shih-Jen Hwang; Kahraman Tanriverdi; Santhi K Ganesh; Nicholas L Smith; Patricia A Peyser; Jane E Freedman; Christopher J O'Donnell
Journal: Hum Mol Genet Date: 2013-09-20 Impact factor: 6.150

Review 3. Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response.

Authors: Athma A Pai; Francesca Luca
Journal: Wiley Interdiscip Rev RNA Date: 2018-09-14 Impact factor: 9.957

9. Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.

Authors: Amy Webb; Audrey C Papp; Jonathan C Sanford; Kun Huang; Jeffrey D Parvin; Wolfgang Sadee
Journal: Pharmacogenet Genomics Date: 2013-05 Impact factor: 2.089

Review 10. The relevance of "missing heritability " in pharmacogenomics.

Authors: W Sadee
Journal: Clin Pharmacol Ther Date: 2012-08-22 Impact factor: 6.875